Metallothionein-2 is a metallothionein protein that in humans is encoded by the MT2A gene.[3][4]

MT2A
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesMT2A, MT2, Metallothionein 2A, MT-II, MT-2
External IDsOMIM: 156360; HomoloGene: 136536; GeneCards: MT2A; OMA:MT2A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005953

n/a

RefSeq (protein)

NP_005944

n/a

Location (UCSC)Chr 16: 56.61 – 56.61 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

The single-nucleotide polymorphism rs28366003 which substitutes guanine for adenine in MT2A is associated with certain cancers and some chronic diseases.[5]

Interactions

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Metallothionein 2A has been shown to interact with protein kinase D1.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125148Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Karin M, Richards RI (Dec 1982). "Human metallothionein genes--primary structure of the metallothionein-II gene and a related processed gene". Nature. 299 (5886): 797–802. Bibcode:1982Natur.299..797K. doi:10.1038/299797a0. PMID 7133118. S2CID 4332683.
  4. ^ "Entrez Gene: MT2A metallothionein 2A".
  5. ^ Sekovanić A, Jurasović J, Piasek M (2020). "Metallothionein 2A gene polymorphisms in relation to diseases and trace element levels in humans". Arhiv Za Higijenu Rada I Toksikologiju. 71 (1): 27–47. doi:10.2478/aiht-2020-71-3349. PMC 7837243. PMID 32597135.
  6. ^ Rao, Prema S; Jaggi Meena; Smith David J; Hemstreet George P; Balaji K C (Oct 2003). "Metallothionein 2A interacts with the kinase domain of PKCmu in prostate cancer". Biochem. Biophys. Res. Commun. 310 (3). United States: 1032–8. doi:10.1016/j.bbrc.2003.09.118. ISSN 0006-291X. PMID 14550308.

Further reading

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