Methanol dehydrogenase (nicotinoprotein) (EC 1.1.99.37, NDMA-dependent methanol dehydrogenase, nicotinoprotein methanol dehydrogenase, methanol:N,N-dimethyl-4-nitrosoaniline oxidoreductase) is an enzyme with systematic name methanol:acceptor oxidoreductase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
| Methanol dehydrogenase (nicotinoprotein) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.99.37 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- methanol + acceptor formaldehyde + reduced acceptor
This enzyme contains Zn2+ and Mg2+.
References
edit- ^ Vonck J, Arfman N, De Vries GE, Van Beeumen J, Van Bruggen EF, Dijkhuizen L (February 1991). "Electron microscopic analysis and biochemical characterization of a novel methanol dehydrogenase from the thermotolerant Bacillus sp. C1". The Journal of Biological Chemistry. 266 (6): 3949–54. PMID 1995642.
- ^ Van Ophem PW, Van Beeumen J, Duine JA (March 1993). "Nicotinoprotein [NAD(P)-containing] alcohol/aldehyde oxidoreductases. Purification and characterization of a novel type from Amycolatopsis methanolica". European Journal of Biochemistry. 212 (3): 819–26. doi:10.1111/j.1432-1033.1993.tb17723.x. PMID 8385013.
- ^ Bystrykh LV, Vonck J, van Bruggen EF, van Beeumen J, Samyn B, Govorukhina NI, Arfman N, Duine JA, Dijkhuizen L (March 1993). "Electron microscopic analysis and structural characterization of novel NADP(H)-containing methanol: N,N'-dimethyl-4-nitrosoaniline oxidoreductases from the gram-positive methylotrophic bacteria Amycolatopsis methanolica and Mycobacterium gastri MB19". Journal of Bacteriology. 175 (6): 1814–22. doi:10.1128/jb.175.6.1814-1822.1993. PMC 203978. PMID 8449887.
- ^ Hektor HJ, Kloosterman H, Dijkhuizen L (December 2002). "Identification of a magnesium-dependent NAD(P)(H)-binding domain in the nicotinoprotein methanol dehydrogenase from Bacillus methanolicus" (PDF). The Journal of Biological Chemistry. 277 (49): 46966–73. doi:10.1074/jbc.M207547200. PMID 12351635.
- ^ Park H, Lee H, Ro YT, Kim YM (February 2010). "Identification and functional characterization of a gene for the methanol : N,N'-dimethyl-4-nitrosoaniline oxidoreductase from Mycobacterium sp. strain JC1 (DSM 3803)". Microbiology. 156 (Pt 2): 463–71. doi:10.1099/mic.0.034124-0. PMID 19875438.
External links
edit- Methanol+dehydrogenase+(nicotinoprotein) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
