In enzymology, a Methanosarcina-phenazine hydrogenase (EC 1.12.98.3) is an enzyme that catalyzes the chemical reaction
| Methanosarcina-phenazine hydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.12.98.3 | ||||||||
| CAS no. | 9027-05-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- H2 + 2-(2,3-dihydropentaprenyloxy)phenazine 2-dihydropentaprenyloxyphenazine
Thus, the two substrates of this enzyme are H2 and 2-(2,3-dihydropentaprenyloxy)phenazine, whereas its product is 2-dihydropentaprenyloxyphenazine.
This enzyme belongs to the family of oxidoreductases, specifically those acting on hydrogen as donor with other, known, acceptors. The systematic name of this enzyme class is hydrogen:2-(2,3-dihydropentaprenyloxy)phenazine oxidoreductase. Other names in common use include methanophenazine hydrogenase, and methylviologen-reducing hydrogenase.
References
edit- Abken HJ, Tietze M, Brodersen J, Baumer S, Beifuss U, Deppenmeier U (1998). "Isolation and characterization of methanophenazine and function of phenazines in membrane-bound electron transport of Methanosarcina mazei Go1". J. Bacteriol. 180 (8): 2027–32. PMC 107126. PMID 9555882.
- Deppenmeier U, Lienard T, Gottschalk G (1999). "Novel reactions involved in energy conservation by methanogenic archaea". FEBS Lett. 457 (3): 291–7. doi:10.1016/S0014-5793(99)01026-1. PMID 10471795.
- Beifuss U, Tietze M, Baumer S, Deppenmeier U (2000). "Methanophenazine: Structure, Total Synthesis, and Function of a New Cofactor from Methanogenic Archaea This work was supported by the Deutsche Forschungsgemeinschaft (Sonderforschungsbereich 416; grants De 488/6-1 and De 488/4-2) and the Fonds der Chemischen Industrie We are grateful to Drs. J. Paust and H. Jaedicke (BASF AG, Ludwigshafen) and Dr. R. K. Muller (Hoffmann-La Roche Ltd., Basel) for generously providing chemicals". Angew. Chem. Int. Ed. Engl. 39 (14): 2470–2472. doi:10.1002/1521-3773(20000717)39:14<2470::AID-ANIE2470>3.0.CO;2-R. PMID 10941105.
