Methylecgonone reductase (EC 1.1.1.334, MecgoR (gene name)) is an enzyme with systematic name ecgonine methyl ester:NADP+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction
| Methylecgonone reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.334 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- ecgonine methyl ester + NADP+ ecgonone methyl ester + NADPH + H+
The enzyme from the plant Erythroxylum coca participates in the biosynthesis of cocaine.
References
edit- ^ Jirschitzka J, Schmidt GW, Reichelt M, Schneider B, Gershenzon J, D'Auria JC (June 2012). "Plant tropane alkaloid biosynthesis evolved independently in the Solanaceae and Erythroxylaceae". Proceedings of the National Academy of Sciences of the United States of America. 109 (26): 10304–9. Bibcode:2012PNAS..10910304J. doi:10.1073/pnas.1200473109. PMC 3387132. PMID 22665766.
External links
edit- Methylecgonone+reductase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
