Methylglutamate dehydrogenase

In enzymology, a methylglutamate dehydrogenase (EC 1.5.99.5) is an enzyme that catalyzes the chemical reaction

methylglutamate dehydrogenase
Identifiers
EC no.1.5.99.5
CAS no.37217-26-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
N-methyl-L-glutamate + acceptor + H2O L-glutamate + formaldehyde + reduced acceptor

The 3 substrates of this enzyme are N-methyl-L-glutamate, acceptor, and H2O, whereas its 3 products are L-glutamate, formaldehyde, and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with other acceptors. The systematic name of this enzyme class is N-methyl-L-glutamate:acceptor oxidoreductase (demethylating). Other names in common use include N-methylglutamate dehydrogenase, and N-methyl-L-glutamate:(acceptor) oxidoreductase (demethylating). This enzyme participates in methane metabolism.

References

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  • Hersh LB, Stark MJ, Worthen S, Fiero MK (1972). "N-methylglutamate dehydrogenase: kinetic studies on the solubilized enzyme". Arch. Biochem. Biophys. 150 (1): 219–26. doi:10.1016/0003-9861(72)90029-X. PMID 5028076.