Mga, max dimerization protein

MGA, MAX dimerization protein is a protein that in humans is encoded by the MGA gene.

MGA
Identifiers
Aliases	MGA, MAD5, MXD5, MAX dimerization protein, MAX dimerization protein MGA
External IDs	OMIM: 616061; MGI: 1352483; HomoloGene: 49351; GeneCards: MGA; OMA:MGA - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q15.1 Start 41,621,134 bp End 41,773,081 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 E5 Start 119,727,709 bp End 119,800,062 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon oocyte tendon of biceps brachii secondary oocyte testicle corpus callosum internal globus pallidus sperm sural nerve pylorus Top expressed in genital tubercle tail of embryo pineal gland cumulus cell Gonadal ridge pituitary gland vas deferens ascending aorta lobe of cerebellum zygote More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding protein binding protein dimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm MLL1 complex Biological process regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of G0 to G1 transition regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23269 29808 Ensembl ENSG00000174197 ENSMUSG00000033943 UniProt Q8IWI9 A2AWL7 RefSeq (mRNA) NM_001080541 NM_001164273 NM_001400225 NM_001400242 NM_001400243 NM_001400244 NM_001400245 NM_001400246 NM_001400247 NM_001164274 NM_013720 RefSeq (protein) NP_001074010 NP_001157745 NP_001157746 NP_038748 Location (UCSC) Chr 15: 41.62 – 41.77 Mb Chr 2: 119.73 – 119.8 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Parsons KS, Hsu AC, Wark PA (January 2014). "TLR3 and MDA5 signalling, although not expression, is impaired in asthmatic epithelial cells in response to rhinovirus infection". Clin. Exp. Allergy. 44 (1): 91–101. doi:10.1111/cea.12218. PMID 24131248. S2CID 24528615.
• Romero OA, Torres-Diz M, Pros E, Savola S, Gomez A, Moran S, Saez C, Iwakawa R, Villanueva A, Montuenga LM, Kohno T, Yokota J, Sanchez-Cespedes M (March 2014). "MAX inactivation in small cell lung cancer disrupts MYC-SWI/SNF programs and is synthetic lethal with BRG1". Cancer Discov. 4 (3): 292–303. doi:10.1158/2159-8290.CD-13-0799. PMID 24362264.
• Duan C, Yang X, Zhang X, Feng J, Liu Z, Que H, Johnson H, Zhao Y, Fan Y, Lu Y, Zhang H, Huang Y, Xiu B, Feng X (August 2015). "Generation of monoclonal antibodies against MGA and comparison of their application in breast cancer detection by immunohistochemistry". Sci Rep. 5: 13073. Bibcode:2015NatSR...513073D. doi:10.1038/srep13073. PMC 4536492. PMID 26272389.