miR-144 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer.[1] In humans, miR-144 has been characterised as a "common miRNA signature"[2] of a number of different tumours.
| miR-144 | |
|---|---|
 Conserved secondary structure of miR-144 precursor microRNA | |
| Identifiers | |
| Symbol | miR-144 |
| Alt. Symbols | MIR144 |
| Rfam | RF00682 |
| miRBase | MI0000460 |
| miRBase family | MIPF0000093 |
| NCBI Gene | 406936 |
| HGNC | 31531 |
| OMIM | 612070 |
| RefSeq | NR_029685 |
| Other data | |
| RNA type | miRNA |
| Domain(s) | Mammalia |
| GO | 0035195 |
| SO | 0001244 |
| Locus | Chr. 17 q11.2 |
| PDB structures | PDBe |
GATA4 is thought to activate transcription of the miR-144 microRNA precursor.[3]
Function
editmiR-144 functions in a cluster with miR-451. This locus regulates the expression of a number of genes whose products are involved in erythropoiesis.[4] One of the identified targets of miR-144 is insulin receptor substrate 1.[5]
Applications
editmiR-144 has been identified as one of a number of potential miRNA targets which could be used to treat schizophrenia and bipolar affective disorder.[6] It has also been suggested as a potential therapeutic tool to treat ischemic heart disease.[3]
References
edit- ^ Ambros V (Dec 2001). "microRNAs: tiny regulators with great potential". Cell. 107 (7): 823–6. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458. S2CID 14574186.
- ^ Wang W, Peng B, Wang D, Ma X, Jiang D, Zhao J, Yu L (Oct 2011). "Human tumor microRNA signatures derived from large-scale oligonucleotide microarray datasets". International Journal of Cancer. 129 (7): 1624–34. doi:10.1002/ijc.25818. PMID 21128228. S2CID 24227118.
- ^ a b Zhang X, Wang X, Zhu H, Zhu C, Wang Y, Pu WT, Jegga AG, Fan GC (Nov 2010). "Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death". Journal of Molecular and Cellular Cardiology. 49 (5): 841–50. doi:10.1016/j.yjmcc.2010.08.007. PMC 2949485. PMID 20708014.
- ^ Rasmussen KD, Simmini S, Abreu-Goodger C, Bartonicek N, Di Giacomo M, Bilbao-Cortes D, Horos R, Von Lindern M, Enright AJ, O'Carroll D (Jul 2010). "The miR-144/451 locus is required for erythroid homeostasis". The Journal of Experimental Medicine. 207 (7): 1351–8. doi:10.1084/jem.20100458. PMC 2901075. PMID 20513743.
- ^ Karolina DS, Armugam A, Tavintharan S, Wong MT, Lim SC, Sum CF, Jeyaseelan K (2011). "MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus". PLOS ONE. 6 (8): e22839. Bibcode:2011PLoSO...622839K. doi:10.1371/journal.pone.0022839. PMC 3148231. PMID 21829658.
- ^ Dinan TG (Apr 2010). "MicroRNAs as a target for novel antipsychotics: a systematic review of an emerging field". The International Journal of Neuropsychopharmacology. 13 (3): 395–404. doi:10.1017/S1461145709990800. PMID 19849891.(subscription required)
Further reading
edit- Zhang HY, Zheng SJ, Zhao JH, Zhao W, Zheng LF, Zhao D, Li JM, Zhang XF, Chen ZB, Yi XN (Apr 2011). "MicroRNAs 144, 145, and 214 are down-regulated in primary neurons responding to sciatic nerve transection". Brain Research. 1383: 62–70. doi:10.1016/j.brainres.2011.01.067. PMID 21276775. S2CID 23575540.
External links
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