Wikipedia

Michael Sternberg

For the Grand Master of the Teutonic Knights, see Michael Küchmeister von Sternberg.

Michael Joseph Ezra Sternberg (born 24 June 1951)[3] is a professor at Imperial College London, where he is director of the Centre for Integrative Systems Biology and Bioinformatics[4] and Head of the Structural bioinformatics Group.[1][5][6][7]

Mike Sternberg
Born
Michael Joseph Ezra Sternberg

(1951-06-24) 24 June 1951 (age 73)[3]
Alma mater
Awards
Scientific career
Fields
Institutions
ThesisStudies of Protein Conformation (1977)
Doctoral advisorDavid Chilton Phillips[2]
Websitewww.imperial.ac.uk/people/m.sternberg

Education

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Sternberg was educated at Hendon County Grammar School and Gonville and Caius College, Cambridge, where he was awarded a Bachelor of Arts degree in natural sciences (theoretical physics) in 1972.[3] He went on to do a Master of Science degree in Computing at Imperial College London followed by a DPhil degree from the University of Oxford (Wolfson College, Oxford) in 1978 for research supervised by David Chilton Phillips.[2][8][9][10][11][12]

Career

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After postdoctoral research at the University of Oxford, Sternberg became a Lecturer in the Department of Crystallography at Birkbeck College, London. He went on to work at the Imperial Cancer Research Fund and joined Imperial College in 2001.[3][13][14][15][16] He is the Director of the Centre for Integrative Systems Biology and Bioinformatics[4] at Imperial College.

Research

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Sternberg's research interests are in protein structure prediction, protein function prediction, prediction of macromolecular docking and interactions, network modelling for systems biology and logic-based drug design.[13][17][18][19][20][21][22][23][24][25]

He has authored or co-authored several books including From Cells to Atoms: an illustrated introduction to molecular biology,[26] Protein Engineering: a practical approach[27] and Protein Structure Prediction: a practical approach.[28]

During his DPhil research at Oxford he worked with Janet Thornton and they undertook some of the first systematic analyses of protein structure. They identified that the beta-alpha-beta unit in proteins is nearly always right handed and this explained remarkable similarities between protein structures.[citation needed]

His group, particularly Lawrence Kelley, have developed the widely used Phyre/Phyre2 web server[29][30][31] for protein structure prediction. This web resource has been used by over 100,000 distinct users worldwide.[citation needed]

Recently his PhD student Chris Yates developed SuSPect,[32] a novel powerful method to predict the phenotypic effects of Single-nucleotide polymorphisms and other amino acid variants.

Awards and honours

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Sternberg was elected a Fellow of the Royal Society of Biology (FRSB) and a Fellow of the Institute of Biology (FIBiol). He is an associate editor of the Journal of Molecular Biology.

References

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  1. ^ a b Michael Sternberg publications indexed by Google Scholar  
  2. ^ a b Sternberg, Michael Joseph Ezra (1977). Studies of protein conformation (DPhil thesis). University of Oxford.
  3. ^ a b c d "STERNBERG, Prof. Michael Joseph Ezra". Who's Who. Vol. 2014 (online Oxford University Press ed.). A & C Black. (Subscription or UK public library membership required.)
  4. ^ a b "Imperial College London".
  5. ^ Michael Sternberg's publications indexed by the Scopus bibliographic database. (subscription required)
  6. ^ Michael J. E. Sternberg at DBLP Bibliography Server  
  7. ^ Michael Sternberg publications indexed by Microsoft Academic
  8. ^ Cohen, F. E.; Sternberg, M. J.; Phillips, D. C.; Kuntz, I. D.; Kollman, P. A. (1980). "A diffusion--collision--adhesion model for the kinetics of myoglobin refolding". Nature. 286 (5773): 632–4. Bibcode:1980Natur.286..632C. doi:10.1038/286632a0. PMID 7402344. S2CID 4348559.
  9. ^ Artymiuk, P. J.; Blake, C. C.; Grace, D. E.; Oatley, S. J.; Phillips, D. C.; Sternberg, M. J. (1979). "Crystallographic studies of the dynamic properties of lysozyme". Nature. 280 (5723): 563–8. Bibcode:1979Natur.280..563A. doi:10.1038/280563a0. PMID 460438. S2CID 32299121.
  10. ^ Sternberg, M. J.; Grace, D. E.; Phillips, D. C. (1979). "Dynamic information from protein crystallography. An analysis of temperature factors from refinement of the hen egg-white lysozyme structure". Journal of Molecular Biology. 130 (3): 231–52. doi:10.1016/0022-2836(79)90539-4. PMID 469942.
  11. ^ Phillips, D. C.; Sternberg, M. J.; Thornton, J. M.; Wilson, I. A. (1978). "An analysis of the structure of triose phosphate isomerase and its comparison with lactate dehydrogenase". Journal of Molecular Biology. 119 (2): 329–51. doi:10.1016/0022-2836(78)90440-0. PMID 633372.
  12. ^ Phillips, D. C.; Rivers, P. S.; Sternberg, M. J.; Thornton, J. M.; Wilson, I. A. (1977). "An analysis of the three-dimensional structure of chicken triose phosphate isomerase". Biochemical Society Transactions. 5 (3): 642–7. doi:10.1042/bst0050642. PMID 902882.
  13. ^ a b Michael Sternberg, Imperial College London
  14. ^ Sternberg, M. J.; Thornton, J. M. (1978). "Prediction of protein structure from amino acid sequence". Biochemical Society Transactions. 6 (6): 1119–23. doi:10.1042/bst0061119. PMID 744369.
  15. ^ Sternberg, M. J.; Thornton, J. M. (1978). "Prediction of protein structure from amino acid sequence". Nature. 271 (5640): 15–20. Bibcode:1978Natur.271...15S. doi:10.1038/271015a0. PMID 342964. S2CID 4160357.
  16. ^ Blundell, T. L.; Sibanda, B. L.; Sternberg, M. J.; Thornton, J. M. (1987). "Knowledge-based prediction of protein structures and the design of novel molecules". Nature. 326 (6111): 347–52. Bibcode:1987Natur.326..347B. doi:10.1038/326347a0. PMID 3550471. S2CID 4330510.
  17. ^ Wass, M. N.; Barton, G.; Sternberg, M. J. E. (2012). "Comb Func: Predicting protein function using heterogeneous data sources". Nucleic Acids Research. 40 (Web Server issue): W466–W470. doi:10.1093/nar/gks489. PMC 3394346. PMID 22641853.
  18. ^ Kelley, L. A.; MacCallum, R. M.; Sternberg, M. J. E. (2000). "Enhanced genome annotation using structural profiles in the program 3D-PSSM". Journal of Molecular Biology. 299 (2): 501–522. doi:10.1006/jmbi.2000.3741. PMID 10860755.
  19. ^ Gabb, H. A.; Jackson, R. M.; Sternberg, M. J. E. (1997). "Modelling protein docking using shape complementarity, electrostatics and biochemical information". Journal of Molecular Biology. 272 (1): 106–20. doi:10.1006/jmbi.1997.1203. PMID 9299341.
  20. ^ Barton, G. J.; Sternberg, M. J. (1987). "A strategy for the rapid multiple alignment of protein sequences. Confidence levels from tertiary structure comparisons". Journal of Molecular Biology. 198 (2): 327–37. doi:10.1016/0022-2836(87)90316-0. PMID 3430611.
  21. ^ Zvelebil, M. J.; Barton, G. J.; Taylor, W. R.; Sternberg, M. J. (1987). "Prediction of protein secondary structure and active sites using the alignment of homologous sequences". Journal of Molecular Biology. 195 (4): 957–61. doi:10.1016/0022-2836(87)90501-8. PMID 3656439.
  22. ^ King, R. D.; Sternberg, M. J. E. (1996). "Identification and application of the concepts important for accurate and reliable protein secondary structure prediction". Protein Science. 5 (11): 2298–2310. doi:10.1002/pro.5560051116. PMC 2143286. PMID 8931148.
  23. ^ Lewis, T. E.; Sillitoe, I; Andreeva, A; Blundell, T. L.; Buchan, D. W.; Chothia, C; Cozzetto, D; Dana, J. M.; Filippis, I; Gough, J; Jones, D. T.; Kelley, L. A.; Kleywegt, G. J.; Minneci, F; Mistry, J; Murzin, A. G.; Ochoa-Montaño, B; Oates, M. E.; Punta, M; Rackham, O. J.; Stahlhacke, J; Sternberg, M. J.; Velankar, S; Orengo, C (2015). "Genome3D: Exploiting structure to help users understand their sequences". Nucleic Acids Research. 43 (Database issue): D382–6. doi:10.1093/nar/gku973. PMC 4384030. PMID 25348407.
  24. ^ Radivojac, P.; Clark, W. T.; Oron, T. R.; Schnoes, A. M.; Wittkop, T.; Sokolov, A.; Graim, K.; Funk, C.; Verspoor, K.; Ben-Hur, A.; Pandey, G.; Yunes, J. M.; Talwalkar, A. S.; Repo, S.; Souza, M. L.; Piovesan, D.; Casadio, R.; Wang, Z.; Cheng, J.; Fang, H.; Gough, J.; Koskinen, P.; Törönen, P.; Nokso-Koivisto, J.; Holm, L.; Cozzetto, D.; Buchan, D. W. A.; Bryson, K.; Jones, D. T.; et al. (2013). "A large-scale evaluation of computational protein function prediction". Nature Methods. 10 (3): 221–227. doi:10.1038/nmeth.2340. PMC 3584181. PMID 23353650.
  25. ^ Lewis, T. E.; Sillitoe, I; Andreeva, A; Blundell, T. L.; Buchan, D. W.; Chothia, C; Cuff, A; Dana, J. M.; Filippis, I; Gough, J; Hunter, S; Jones, D. T.; Kelley, L. A.; Kleywegt, G. J.; Minneci, F; Mitchell, A; Murzin, A. G.; Ochoa-Montaño, B; Rackham, O. J.; Smith, J; Sternberg, M. J.; Velankar, S; Yeats, C; Orengo, C (2013). "Genome3D: A UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains". Nucleic Acids Research. 41 (Database issue): D499–507. doi:10.1093/nar/gks1266. PMC 3531217. PMID 23203986.
  26. ^ From Cells to Atoms: an illustrated introduction to molecular biology ISBN 0632008881
  27. ^ Protein Engineering: a practical approach ISBN 0199631387
  28. ^ Protein Structure Prediction: a practical approach ISBN 0199634963|
  29. ^ Kelley, L. A.; Sternberg, M. J. E. (2009). "Protein structure prediction on the Web: A case study using the Phyre server". Nature Protocols. 4 (3): 363–71. doi:10.1038/nprot.2009.2. hdl:10044/1/18157. PMID 19247286. S2CID 12497300.
  30. ^ Bennett-Lovsey, R. M.; Herbert, A. D.; Sternberg, M. J. E.; Kelley, L. A. (2007). "Exploring the extremes of sequence/structure space with ensemble fold recognition in the program Phyre". Proteins: Structure, Function, and Bioinformatics. 70 (3): 611–625. doi:10.1002/prot.21688. PMID 17876813. S2CID 23530683.
  31. ^ "Redirecting to Phyre2".
  32. ^ Yates, C. M.; Filippis, I; Kelley, L. A.; Sternberg, M. J. (2014). "SuSPect: Enhanced prediction of single amino acid variant (SAV) phenotype using network features". Journal of Molecular Biology. 426 (14): 2692–701. doi:10.1016/j.jmb.2014.04.026. PMC 4087249. PMID 24810707.
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