In molecular biology mir-202 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. The pre-miR-202 in the mouse genome is located fully within an exon, whereas in human it lies across a splice junction. This implies that human miR-202 is exposed to a negative regulation by splicing, whereas murine miR-202 is not.[1]
| mir-202 | |
|---|---|
| Identifiers | |
| Symbol | mir-202 |
| Rfam | RF00705 |
| miRBase family | 6 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
See also
editReferences
edit- ^ Melamed Z, Levy A, Ashwal-Fluss R, Lev-Maor G, Mekahel K, Atias N, Gilad S, Sharan R, Levy C, Kadener S, Ast G (June 2013). "Alternative splicing regulates biogenesis of miRNAs located across exon-intron junctions". Molecular Cell. 50 (6): 869–81. doi:10.1016/j.molcel.2013.05.007. PMID 23747012.
Further reading
edit- Schrauder MG, Strick R, Schulz-Wendtland R, Strissel PL, Kahmann L, Loehberg CR, Lux MP, Jud SM, Hartmann A, Hein A, Bayer CM, Bani MR, Richter S, Adamietz BR, Wenkel E, Rauh C, Beckmann MW, Fasching PA (2012). Hoheisel JD (ed.). "Circulating micro-RNAs as potential blood-based markers for early stage breast cancer detection". PLOS ONE. 7 (1): e29770. Bibcode:2012PLoSO...729770S. doi:10.1371/journal.pone.0029770. PMC 3252341. PMID 22242178.
- Buechner J, Tømte E, Haug BH, Henriksen JR, Løkke C, Flægstad T, Einvik C (July 2011). "Tumour-suppressor microRNAs let-7 and mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastoma". British Journal of Cancer. 105 (2): 296–303. doi:10.1038/bjc.2011.220. PMC 3142803. PMID 21654684.
- Nymark P, Guled M, Borze I, Faisal A, Lahti L, Salmenkivi K, Kettunen E, Anttila S, Knuutila S (August 2011). "Integrative analysis of microRNA, mRNA and aCGH data reveals asbestos- and histology-related changes in lung cancer". Genes, Chromosomes & Cancer. 50 (8): 585–97. doi:10.1002/gcc.20880. PMID 21563230. S2CID 39556202.
- Hawkins SM, Creighton CJ, Han DY, Zariff A, Anderson ML, Gunaratne PH, Matzuk MM (May 2011). "Functional microRNA involved in endometriosis". Molecular Endocrinology. 25 (5): 821–32. doi:10.1210/me.2010-0371. PMC 3082329. PMID 21436257.
- Muráni E, Ponsuksili S, D'Eath RB, Turner SP, Evans G, Thölking L, Kurt E, Klont R, Foury A, Mormède P, Wimmers K (June 2011). "Differential mRNA expression of genes in the porcine adrenal gland associated with psychosocial stress". Journal of Molecular Endocrinology. 46 (3): 165–74. doi:10.1530/JME-10-0147. PMID 21266515.
- Pizzimenti S, Ferracin M, Sabbioni S, Toaldo C, Pettazzoni P, Dianzani MU, Negrini M, Barrera G (January 2009). "MicroRNA expression changes during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal, a product of lipid peroxidation". Free Radical Biology & Medicine. 46 (2): 282–8. doi:10.1016/j.freeradbiomed.2008.10.035. PMID 19022373.
External links
edit
 | This genetics article is a stub. You can help Wikipedia by expanding it. |