mir-25 microRNA precursor family

In molecular biology mir-25 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. mir-25 levels increase in human heart failure, and treatment with an anti-sense RNA molecule (antagomiR) was recently reported to halt disease progression and improves cardiac function in a mouse heart failure model.

mir-25
Identifiers
Symbol	mir-25
Rfam	RF02020
miRBase family	25
Other data
RNA type	microRNA
Domain(s)	Eukaryota;
PDB structures	PDBe

See also

• MicroRNA

Further reading

• Kwok HH, Yue PY, Mak NK, Wong RN (August 2012). "Ginsenoside Rb₁ induces type I collagen expression through peroxisome proliferator-activated receptor-delta". Biochemical Pharmacology. 84 (4): 532–9. doi:10.1016/j.bcp.2012.05.023. PMID 22692056.
• Nishida N, Nagahara M, Sato T, Mimori K, Sudo T, Tanaka F, Shibata K, Ishii H, Sugihara K, Doki Y, Mori M (June 2012). "Microarray analysis of colorectal cancer stromal tissue reveals upregulation of two oncogenic miRNA clusters". Clinical Cancer Research. 18 (11): 3054–70. doi:10.1158/1078-0432.CCR-11-1078. PMID 22452939.
• Xu X, Chen Z, Zhao X, Wang J, Ding D, Wang Z, Tan F, Tan X, Zhou F, Sun J, Sun N, Gao Y, Shao K, Li N, Qiu B, He J (May 2012). "MicroRNA-25 promotes cell migration and invasion in esophageal squamous cell carcinoma". Biochemical and Biophysical Research Communications. 421 (4): 640–5. doi:10.1016/j.bbrc.2012.03.048. PMID 22450326.
• Suh SS, Yoo JY, Nuovo GJ, Jeon YJ, Kim S, Lee TJ, Kim T, Bakàcs A, Alder H, Kaur B, Aqeilan RI, Pichiorri F, Croce CM (April 2012). "MicroRNAs/TP53 feedback circuitry in glioblastoma multiforme". Proceedings of the National Academy of Sciences of the United States of America. 109 (14): 5316–21. doi:10.1073/pnas.1202465109. PMC 3325690. PMID 22431589.
• Esposito F, Tornincasa M, Pallante P, Federico A, Borbone E, Pierantoni GM, Fusco A (May 2012). "Down-regulation of the miR-25 and miR-30d contributes to the development of anaplastic thyroid carcinoma targeting the polycomb protein EZH2". The Journal of Clinical Endocrinology and Metabolism. 97 (5): E710-8. doi:10.1210/jc.2011-3068. PMID 22399519.
• Wu Q, Wang C, Lu Z, Guo L, Ge Q (July 2012). "Analysis of serum genome-wide microRNAs for breast cancer detection". Clinica Chimica Acta; International Journal of Clinical Chemistry. 413 (13–14): 1058–65. doi:10.1016/j.cca.2012.02.016. PMID 22387599.
• Zhang S, Chen H, Zhao X, Cao J, Tong J, Lu J, Wu W, Shen H, Wei Q, Lu D (January 2013). "REV3L 3'UTR 460 T>C polymorphism in microRNA target sites contributes to lung cancer susceptibility". Oncogene. 32 (2): 242–50. doi:10.1038/onc.2012.32. PMID 22349819.
• Ciuffreda L, Di Sanza C, Cesta Incani U, Eramo A, Desideri M, Biagioni F, Passeri D, Falcone I, Sette G, Bergamo P, Anichini A, Sabapathy K, McCubrey JA, Ricciardi MR, Tafuri A, Blandino G, Orlandi A, De Maria R, Cognetti F, Del Bufalo D, Milella M (June 2012). "The mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms". Journal of Molecular Medicine. 90 (6): 667–79. doi:10.1007/s00109-011-0844-1. PMID 22215152. S2CID 17963454.
• Zhang H, Zuo Z, Lu X, Wang L, Wang H, Zhu Z (February 2012). "MiR-25 regulates apoptosis by targeting Bim in human ovarian cancer". Oncology Reports. 27 (2): 594–8. doi:10.3892/or.2011.1530. PMID 22076535.
• Anton R, Chatterjee SS, Simundza J, Cowin P, Dasgupta R (2011). Bellusci S (ed.). "A systematic screen for micro-RNAs regulating the canonical Wnt pathway". PLOS ONE. 6 (10): e26257. doi:10.1371/journal.pone.0026257. PMC 3197157. PMID 22043311.
• Park YG, Lee KH, Lee JK, Lee KT, Choi DW, Choi SH, Heo JS, Jang KT, Lee EM, Kim JO, Min SY, Kim EJ (October 2011). "[MicroRNA expression pattern in intraductal papillary mucinous neoplasm]". The Korean Journal of Gastroenterology = Taehan Sohwagi Hakhoe Chi. 58 (4): 190–200. doi:10.4166/kjg.2011.58.4.190. PMID 22042419.
• Razumilava N, Bronk SF, Smoot RL, Fingas CD, Werneburg NW, Roberts LR, Mott JL (February 2012). "miR-25 targets TNF-related apoptosis inducing ligand (TRAIL) death receptor-4 and promotes apoptosis resistance in cholangiocarcinoma". Hepatology. 55 (2): 465–75. doi:10.1002/hep.24698. PMC 3268937. PMID 21953056.
• Leite KR, Tomiyama A, Reis ST, Sousa-Canavez JM, Sañudo A, Camara-Lopes LH, Srougi M (August 2013). "MicroRNA expression profiles in the progression of prostate cancer--from high-grade prostate intraepithelial neoplasia to metastasis". Urologic Oncology. 31 (6): 796–801. doi:10.1016/j.urolonc.2011.07.002. PMID 21880514.
• Zhu L, Yan W, Rodriguez-Canales J, Rosenberg AM, Hu N, Goldstein AM, Taylor PR, Erickson HS, Emmert-Buck MR, Tangrea MA (2011). "MicroRNA analysis of microdissected normal squamous esophageal epithelium and tumor cells". American Journal of Cancer Research. 1 (5): 574–584. PMC 3142940. PMID 21796275.
• Li X, Zhang Y, Zhang H, Liu X, Gong T, Li M, Sun L, Ji G, Shi Y, Han Z, Han S, Nie Y, Chen X, Zhao Q, Ding J, Wu K, Daiming F (July 2011). "miRNA-223 promotes gastric cancer invasion and metastasis by targeting tumor suppressor EPB41L3". Molecular Cancer Research. 9 (7): 824–33. doi:10.1158/1541-7786.MCR-10-0529. PMID 21628394.
• Gunaratne PH, Lin YC, Benham AL, Drnevich J, Coarfa C, Tennakoon JB, Creighton CJ, Kim JH, Milosavljevic A, Watson M, Griffiths-Jones S, Clayton DF (May 2011). "Song exposure regulates known and novel microRNAs in the zebra finch auditory forebrain". BMC Genomics. 12 (1): 277. doi:10.1186/1471-2164-12-277. PMC 3118218. PMID 21627805.
• Brett JO, Renault VM, Rafalski VA, Webb AE, Brunet A (February 2011). "The microRNA cluster miR-106b~25 regulates adult neural stem/progenitor cell proliferation and neuronal differentiation". Aging. 3 (2): 108–24. doi:10.18632/aging.100285. PMC 3082007. PMID 21386132.
• Xie T, Liang J, Guo R, Liu N, Noble PW, Jiang D (May 2011). "Comprehensive microRNA analysis in bleomycin-induced pulmonary fibrosis identifies multiple sites of molecular regulation". Physiological Genomics. 43 (9): 479–87. doi:10.1152/physiolgenomics.00222.2010. PMC 3110895. PMID 21266501.
• Zhang Z, O'Rourke JR, McManus MT, Lewandoski M, Harfe BD, Sun X (March 2011). "The microRNA-processing enzyme Dicer is dispensable for somite segmentation but essential for limb bud positioning". Developmental Biology. 351 (2): 254–65. doi:10.1016/j.ydbio.2011.01.005. PMC 3541530. PMID 21256124.
• Scapoli L, Palmieri A, Lo Muzio L, Pezzetti F, Rubini C, Girardi A, Farinella F, Mazzotta M, Carinci F (2010). "MicroRNA expression profiling of oral carcinoma identifies new markers of tumor progression". International Journal of Immunopathology and Pharmacology. 23 (4): 1229–34. doi:10.1177/039463201002300427. hdl:11585/106742. PMID 21244772. S2CID 21890748.
• Birks DK, Barton VN, Donson AM, Handler MH, Vibhakar R, Foreman NK (February 2011). "Survey of MicroRNA expression in pediatric brain tumors". Pediatric Blood & Cancer. 56 (2): 211–6. doi:10.1002/pbc.22723. PMID 21157891. S2CID 12955063.
• Li LM, Hu ZB, Zhou ZX, Chen X, Liu FY, Zhang JF, Shen HB, Zhang CY, Zen K (December 2010). "Serum microRNA profiles serve as novel biomarkers for HBV infection and diagnosis of HBV-positive hepatocarcinoma". Cancer Research. 70 (23): 9798–807. doi:10.1158/0008-5472.CAN-10-1001. PMID 21098710.
• Wang Y, Scheiber MN, Neumann C, Calin GA, Zhou D (November 2011). "MicroRNA regulation of ionizing radiation-induced premature senescence". International Journal of Radiation Oncology, Biology, Physics. 81 (3): 839–48. doi:10.1016/j.ijrobp.2010.09.048. PMC 3056910. PMID 21093163.
• Fu Y, Zhang Y, Wang Z, Wang L, Wei X, Zhang B, Wen Z, Fang H, Pang Q, Yi F (2010). "Regulation of NADPH oxidase activity is associated with miRNA-25-mediated NOX4 expression in experimental diabetic nephropathy". American Journal of Nephrology. 32 (6): 581–9. doi:10.1159/000322105. PMID 21071935. S2CID 31810215.
• Kumar M, Lu Z, Takwi AA, Chen W, Callander NS, Ramos KS, Young KH, Li Y (February 2011). "Negative regulation of the tumor suppressor p53 gene by microRNAs". Oncogene. 30 (7): 843–53. doi:10.1038/onc.2010.457. PMC 3021102. PMID 20935678.
• Dacic S, Kelly L, Shuai Y, Nikiforova MN (December 2010). "miRNA expression profiling of lung adenocarcinomas: correlation with mutational status". Modern Pathology. 23 (12): 1577–82. doi:10.1038/modpathol.2010.152. PMID 20818338.
• De Santis G, Ferracin M, Biondani A, Caniatti L, Rosaria Tola M, Castellazzi M, Zagatti B, Battistini L, Borsellino G, Fainardi E, Gavioli R, Negrini M, Furlan R, Granieri E (September 2010). "Altered miRNA expression in T regulatory cells in course of multiple sclerosis". Journal of Neuroimmunology. 226 (1–2): 165–71. doi:10.1016/j.jneuroim.2010.06.009. PMID 20637509. S2CID 35926309.
• Cheever A, Blackwell E, Ceman S (August 2010). "Fragile X protein family member FXR1P is regulated by microRNAs". RNA. 16 (8): 1530–9. doi:10.1261/rna.2022210. PMC 2905753. PMID 20519410.
• Poliseno L, Salmena L, Riccardi L, Fornari A, Song MS, Hobbs RM, Sportoletti P, Varmeh S, Egia A, Fedele G, Rameh L, Loda M, Pandolfi PP (April 2010). "Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation". Science Signaling. 3 (117): ra29. doi:10.1126/scisignal.2000594. PMC 2982149. PMID 20388916.
• Wang Y, Li Z, He C, Wang D, Yuan X, Chen J, Jin J (March 2010). "MicroRNAs expression signatures are associated with lineage and survival in acute leukemias". Blood Cells, Molecules & Diseases. 44 (3): 191–7. doi:10.1016/j.bcmd.2009.12.010. PMC 2829339. PMID 20110180.
• Zhu Z, He J, Jia X, Jiang J, Bai R, Yu X, Lv L, Fan R, He X, Geng J, You R, Dong Y, Qiao D, Lee KB, Smith GW, Dong C (April 2010). "MicroRNA-25 functions in regulation of pigmentation by targeting the transcription factor MITF in Alpaca (Lama pacos) skin melanocytes". Domestic Animal Endocrinology. 38 (3): 200–9. doi:10.1016/j.domaniend.2009.10.004. PMID 20036482.
• Divakaran V, Adrogue J, Ishiyama M, Entman ML, Haudek S, Sivasubramanian N, Mann DL (November 2009). "Adaptive and maladptive effects of SMAD3 signaling in the adult heart after hemodynamic pressure overloading". Circulation: Heart Failure. 2 (6): 633–42. doi:10.1161/CIRCHEARTFAILURE.108.823070. PMC 3064555. PMID 19919989.
• Marasa BS, Srikantan S, Masuda K, Abdelmohsen K, Kuwano Y, Yang X, Martindale JL, Rinker-Schaeffer CW, Gorospe M (October 2009). "Increased MKK4 abundance with replicative senescence is linked to the joint reduction of multiple microRNAs". Science Signaling. 2 (94): ra69. doi:10.1126/scisignal.2000442. PMC 2770878. PMID 19861690.
• Malzkorn B, Wolter M, Liesenberg F, Grzendowski M, Stühler K, Meyer HE, Reifenberger G (May 2010). "Identification and functional characterization of microRNAs involved in the malignant progression of gliomas". Brain Pathology. 20 (3): 539–50. doi:10.1111/j.1750-3639.2009.00328.x. PMC 8094849. PMID 19775293.
• Kuhn AR, Schlauch K, Lao R, Halayko AJ, Gerthoffer WT, Singer CA (April 2010). "MicroRNA expression in human airway smooth muscle cells: role of miR-25 in regulation of airway smooth muscle phenotype". American Journal of Respiratory Cell and Molecular Biology. 42 (4): 506–13. doi:10.1165/rcmb.2009-0123OC. PMC 2848741. PMID 19541842.
• Li Y, Tan W, Neo TW, Aung MO, Wasser S, Lim SG, Tan TM (July 2009). "Role of the miR-106b-25 microRNA cluster in hepatocellular carcinoma". Cancer Science. 100 (7): 1234–42. doi:10.1111/j.1349-7006.2009.01164.x. PMID 19486339.
• Kan T, Sato F, Ito T, Matsumura N, David S, Cheng Y, Agarwal R, Paun BC, Jin Z, Olaru AV, Selaru FM, Hamilton JP, Yang J, Abraham JM, Mori Y, Meltzer SJ (May 2009). "The miR-106b-25 polycistron, activated by genomic amplification, functions as an oncogene by suppressing p21 and Bim". Gastroenterology. 136 (5): 1689–700. doi:10.1053/j.gastro.2009.02.002. PMC 2887605. PMID 19422085.
• Kim YK, Yu J, Han TS, Park SY, Namkoong B, Kim DH, Hur K, Yoo MW, Lee HJ, Yang HK, Kim VN (April 2009). "Functional links between clustered microRNAs: suppression of cell-cycle inhibitors by microRNA clusters in gastric cancer". Nucleic Acids Research. 37 (5): 1672–81. doi:10.1093/nar/gkp002. PMC 2655672. PMID 19153141.
• Qian S, Ding JY, Xie R, An JH, Ao XJ, Zhao ZG, Sun JG, Duan YZ, Chen ZT, Zhu B (December 2008). "MicroRNA expression profile of bronchioalveolar stem cells from mouse lung". Biochemical and Biophysical Research Communications. 377 (2): 668–673. doi:10.1016/j.bbrc.2008.10.052. PMID 18948085.
• Aagaard LA, Zhang J, von Eije KJ, Li H, Saetrom P, Amarzguioui M, Rossi JJ (December 2008). "Engineering and optimization of the miR-106b cluster for ectopic expression of multiplexed anti-HIV RNAs". Gene Therapy. 15 (23): 1536–49. doi:10.1038/gt.2008.147. PMC 3155610. PMID 18800151.
• Palmieri A, Pezzetti F, Spinelli G, Arlotti M, Avantaggiato A, Scarano A, Scapoli L, Zollino I, Carinci F (October 2008). "PerioGlas regulates osteoblast RNA interfering". Journal of Prosthodontics. 17 (7): 522–6. doi:10.1111/j.1532-849X.2008.00331.x. PMID 18573151.
• Huang J, Liang Z, Yang B, Tian H, Ma J, Zhang H (November 2007). "Derepression of microRNA-mediated protein translation inhibition by apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G) and its family members". The Journal of Biological Chemistry. 282 (46): 33632–40. doi:10.1074/jbc.M705116200. PMID 17848567.
• Palmieri A, Pezzetti F, Brunelli G, Zollino I, Scapoli L, Martinelli M, Arlotti M, Carinci F (November 2007). "Differences in osteoblast miRNA induced by cell binding domain of collagen and silicate-based synthetic bone". Journal of Biomedical Science. 14 (6): 777–82. doi:10.1007/s11373-007-9193-z. PMID 17653614.
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External links

• Page for mir-25 microRNA precursor family at Rfam