In molecular biology mir-590 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
| mir-590 | |
|---|---|
| Identifiers | |
| Symbol | mir-590 |
| Rfam | RF00928 |
| miRBase family | MIPF0000418 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
Nicotine-induced atrial remodelling
editDownregulation of miR-590 by nicotine has been found to play a key part in the generation of atrial fibrosis by atrial structural remodelling. This downregulation sees the removal of post-transcriptional repression of TGF-β1 and TGF-β receptor type II (TGF-βRII), and consequent collagen production.[1] miR-590 downregulation has further been shown to be mediated by activation of alpha-7 nicotinic acetylcholine receptors (α7-nAChRs).
See also
editReferences
edit- ^ Shan H, Zhang Y, Lu Y, Zhang Y, Pan Z, Cai B, Wang N, Li X, Feng T, Hong Y, Yang B (August 2009). "Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines". Cardiovascular Research. 83 (3): 465–72. doi:10.1093/cvr/cvp130. PMID 19398468.
Further reading
edit- Monteys AM, Spengler RM, Wan J, Tecedor L, Lennox KA, Xing Y, Davidson BL (March 2010). "Structure and activity of putative intronic miRNA promoters". RNA. 16 (3): 495–505. doi:10.1261/rna.1731910. PMC 2822915. PMID 20075166.
External links
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