mir-616 microRNA is a short non-coding RNA molecule belonging both to the family of microRNAs and to that of small interfering RNAs (siRNAs). MicroRNAs function to regulate the expression levels of other genes by several mechanisms, whilst siRNAs are involved primarily with the RNA interference (RNAi) pathway. miR-616 has been found to induce the specifically androgen-independent growth of prostate cancer cells.[1]
| mir-616 | |
|---|---|
| Identifiers | |
| Symbol | mir-616 |
| Rfam | RF00995 |
| miRBase family | MIPF0000507 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota |
| PDB structures | PDBe |
miR-616 and prostate cancer
editmiR-616 overexpression has been observed in androgen-independent prostate cancer cells, specifically in malignant tissue compared with benign forms. It is notably resistant to castration in LNCaP cells, due to an enhanced ability to proliferate in vivo.[1] It has been found to interact with the tissue factor pathway inhibitor TFPI-2, and to directly target its mRNA at the three 3'UTR. Further, inhibition of TFPI-2 by miR-616 means inversely correlated expression of the two.
See also
editReferences
edit- ^ a b Ma S, Chan YP, Kwan PS, Lee TK, Yan M, Tang KH, et al. (2011). "MicroRNA-616 induces androgen-independent growth of prostate cancer cells by suppressing expression of tissue factor pathway inhibitor TFPI-2". Cancer Res. 71 (2): 583–92. doi:10.1158/0008-5472.CAN-10-2587. PMID 21224345.
Further reading
edit- Huang, Y.; Suo, A. L.; Li, Z. F.; Liu, L. Y.; Tian, T.; Ni, L.; Zhang, W. G.; Nan, K. J.; Song, T. S.; Huang, C. (2009). "MicroRNA profiling of human gastric cancer". Molecular Medicine Reports. 2 (6): 963–970. doi:10.3892/mmr_00000199. PMID 21475928.
- Castelli, E. C.; Moreau, P.; Oya e Chiromatzo, A. O. E.; Mendes-Junior, C. T.; Veiga-Castelli, L. C.; Yaghi, L.; Giuliatti, S.; Carosella, E. D.; Donadi, E. A. (2009). "In silico analysis of microRNAS targeting the HLA-G 3′ untranslated region alleles and haplotypes". Human Immunology. 70 (12): 1020–1025. doi:10.1016/j.humimm.2009.07.028. PMID 19664672.
External links
edit
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