mir-618 microRNA is a short non-coding RNA molecule belonging both to the family of microRNAs and to that of small interfering RNAs (siRNAs). MicroRNAs function to regulate the expression levels of other genes by several mechanisms, whilst siRNAs are involved primarily with the RNA interference (RNAi) pathway.
| mir-618 | |
|---|---|
| Identifiers | |
| Symbol | mir-618 |
| Rfam | RF01034 |
| miRBase family | MIPF0000553 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota |
| PDB structures | PDBe |
miR-618 in oestrogen treatment
editDecreased levels of miR-618 have been observed in estradiol(E2)-stimulated MCF-7 breast cancer cells following hormone deprivation. Intracellular miR-618 levels can be regulated by E2 via the ER2 receptor. This points towards a possible of this miRNA, amongst others, in modulating the final gene responses to the oestrogen family of hormones in breast cancer cells.[1]
Microgravity effects in lymphoblastoid cells
editAltered expression of miR-618 has been seen in the human lymphoblastoid TK6 cell line, with downregulation following stress-related stimulated microgravity in TK6 cells. This further influences several genes involved in regulation of the NF-κB-related pathway network.[2]
See also
editReferences
edit- ^ Cicatiello L, Mutarelli M, Grober OM, Paris O, Ferraro L, Ravo M, Tarallo R, Luo S, Schroth GP, Seifert M, Zinser C, Chiusano ML, Traini A, De Bortoli M, Weisz A (May 2010). "Estrogen receptor alpha controls a gene network in luminal-like breast cancer cells comprising multiple transcription factors and microRNAs". The American Journal of Pathology. 176 (5): 2113–30. doi:10.2353/ajpath.2010.090837. PMC 2861078. PMID 20348243.
- ^ Mangala LS, Zhang Y, He Z, Emami K, Ramesh GT, Story M, Rohde LH, Wu H (September 2011). "Effects of simulated microgravity on expression profile of microRNA in human lymphoblastoid cells". The Journal of Biological Chemistry. 286 (37): 32483–90. doi:10.1074/jbc.M111.267765. PMC 3173213. PMID 21775437.
Further reading
edit- Abdalla MA, Haj-Ahmad Y (2012). "Promising Candidate Urinary MicroRNA Biomarkers for the Early Detection of Hepatocellular Carcinoma among High-Risk Hepatitis C Virus Egyptian Patients". Journal of Cancer. 3: 19–31. doi:10.7150/jca.3.19. PMC 3245605. PMID 22211142.
- Zhang M, Jin M, Yu Y, Zhang S, Wu Y, Liu H, Liu H, Chen B, Li Q, Ma X, Chen K (March 2012). "Associations of miRNA polymorphisms and female physiological characteristics with breast cancer risk in Chinese population". European Journal of Cancer Care. 21 (2): 274–80. doi:10.1111/j.1365-2354.2011.01308.x. PMID 22074121.
External links
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