In molecular biology mir-625 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. Many microRNAs play important roles in cancer development and progression.
| mir-625 | |
|---|---|
| Identifiers | |
| Symbol | mir-625 |
| Rfam | RF01017 |
| miRBase family | MIPF0000534 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
mir-625 and gastric cancer
editmir-625 has been shown to be down regulated in gastric cancers. This is important, as mir-625 is responsible for the regulation of metastasis in gastric tumour cells, and therefore downregulation of mir-625 results in increased metastasis.[1] mir-625 is thought to act by inhibiting the ILK protein.[1]
References
edit- ^ a b Wang M, Li C, Nie H, Lv X, Qu Y, Yu B, Su L, Li J, Chen X, Ju J, Yu Y, Yan M, Gu Q, Zhu Z, Liu B (July 2012). "Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK". FEBS Letters. 586 (16): 2382–8. doi:10.1016/j.febslet.2012.05.050. PMID 22677169.
Further reading
edit- Roth C, Stückrath I, Pantel K, Izbicki JR, Tachezy M, Schwarzenbach H (2012). Lau KM (ed.). "Low levels of cell-free circulating miR-361-3p and miR-625* as blood-based markers for discriminating malignant from benign lung tumors". PLOS ONE. 7 (6): e38248. Bibcode:2012PLoSO...738248R. doi:10.1371/journal.pone.0038248. PMC 3366929. PMID 22675530.
- Bae J, Won M, Kim DY, Kim JH, Kim YM, Kim YT, Nam JH, Suh DS (May 2012). "Identification of differentially expressed microRNAs in endometrial cancer cells after progesterone treatment". International Journal of Gynecological Cancer. 22 (4): 561–5. doi:10.1097/IGC.0b013e31824927db. PMID 22543862. S2CID 205679152.
- Huang JJ, Yu J, Li JY, Liu YT, Zhong RQ (December 2012). "Circulating microRNA expression is associated with genetic subtype and survival of multiple myeloma". Medical Oncology. 29 (4): 2402–8. doi:10.1007/s12032-012-0210-3. PMID 22447484. S2CID 35901851.
- Yu J, Li A, Hong SM, Hruban RH, Goggins M (February 2012). "MicroRNA alterations of pancreatic intraepithelial neoplasias". Clinical Cancer Research. 18 (4): 981–92. doi:10.1158/1078-0432.CCR-11-2347. PMC 3288338. PMID 22114139.
- Xu YW, Wang B, Ding CH, Li T, Gu F, Zhou C (June 2011). "Differentially expressed micoRNAs in human oocytes". Journal of Assisted Reproduction and Genetics. 28 (6): 559–66. doi:10.1007/s10815-011-9590-0. PMC 3158253. PMID 21647640.
- Xu L, Liang YN, Luo XQ, Liu XD, Guo HX (March 2011). "[Association of miRNAs expression profiles with prognosis and relapse in childhood acute lymphoblastic leukemia]". Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi. 32 (3): 178–81. PMID 21535956.
External links
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