In molecular biology mir-638 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
| mir-638 | |
|---|---|
| Identifiers | |
| Symbol | mir-638 |
| Rfam | RF00978 |
| miRBase family | MIPF0000486 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
Expression in lupus nephritis
editmiR-638 has been implicated in the pathogenesis of lupus nephritis (LN), with intra-renal expression levels differing between normal and lupus nephritis patients.[1] The degree of difference in expression levels further correlates with the degree of disease severity in each LN patient.
miR-638 and gastric cancer
editmiR-638 levels are significantly downregulated in gastric cancer cell lines, along with deregulation of 23 other miRNAs.[2] Thus miR-628 is likely to be involved in the development and progression of gastric cancer.
Further applications
editmiR-638 has additionally been found to be upregulated in the K562 leukaemic cell line.[3]
See also
editReferences
edit- ^ Lu J, Kwan BC, Lai FM, Tam LS, Li EK, Chow KM, Wang G, Li PK, Szeto CC (May 2012). "Glomerular and tubulointerstitial miR-638, miR-198 and miR-146a expression in lupus nephritis". Nephrology. 17 (4): 346–51. doi:10.1111/j.1440-1797.2012.01573.x. PMID 22295894. S2CID 24163790.
- ^ Yao Y, Suo AL, Li ZF, Liu LY, Tian T, Ni L, Zhang WG, Nan KJ, Song TS, Huang C (2009). "MicroRNA profiling of human gastric cancer". Molecular Medicine Reports. 2 (6): 963–70. doi:10.3892/mmr_00000199. PMID 21475928.
- ^ Yang Y, Wang LL, Li YH, Gao XN, Yu L (April 2011). "[Expression level of miRNA-663 in different leukemic cell lines and its biological function]". Zhongguo Shi Yan Xue Ye Xue Za Zhi. 19 (2): 279–83. PMID 21518471.
Further reading
edit- Jaiswal R, Luk F, Gong J, Mathys JM, Grau GE, Bebawy M (June 2012). "Microparticle conferred microRNA profiles--implications in the transfer and dominance of cancer traits". Molecular Cancer. 11 (1): 37. doi:10.1186/1476-4598-11-37. PMC 3499176. PMID 22682234.
- Zhu DX, Zhu W, Fang C, Fan L, Zou ZJ, Wang YH, Liu P, Hong M, Miao KR, Liu P, Xu W, Li JY (July 2012). "miR-181a/b significantly enhances drug sensitivity in chronic lymphocytic leukemia cells via targeting multiple anti-apoptosis genes". Carcinogenesis. 33 (7): 1294–301. doi:10.1093/carcin/bgs179. PMID 22610076.
- Wu C, Lin H, Wang Q, Chen W, Luo H, Chen W, Zhang H (June 2012). "Discrepant expression of microRNAs in transparent and cataractous human lenses". Investigative Ophthalmology & Visual Science. 53 (7): 3906–12. doi:10.1167/iovs.11-9178. PMID 22562507.
- Sand M, Skrygan M, Sand D, Georgas D, Hahn SA, Gambichler T, Altmeyer P, Bechara FG (October 2012). "Expression of microRNAs in basal cell carcinoma". The British Journal of Dermatology. 167 (4): 847–55. doi:10.1111/j.1365-2133.2012.11022.x. PMID 22540308. S2CID 8032687.
- Li D, Wang Q, Liu C, Duan H, Zeng X, Zhang B, Li X, Zhao J, Tang S, Li Z, Xing X, Yang P, Chen L, Zeng J, Zhu X, Zhang S, Zhang Z, Ma L, He Z, Wang E, Xiao Y, Zheng Y, Chen W (February 2012). "Aberrant expression of miR-638 contributes to benzo(a)pyrene-induced human cell transformation". Toxicological Sciences. 125 (2): 382–91. doi:10.1093/toxsci/kfr299. PMC 3355321. PMID 22048643.
- Marques FZ, Campain AE, Tomaszewski M, Zukowska-Szczechowska E, Yang YH, Charchar FJ, Morris BJ (December 2011). "Gene expression profiling reveals renin mRNA overexpression in human hypertensive kidneys and a role for microRNAs". Hypertension. 58 (6): 1093–8. doi:10.1161/HYPERTENSIONAHA.111.180729. PMID 22042811.
- Kahlert C, Klupp F, Brand K, Lasitschka F, Diederichs S, Kirchberg J, Rahbari N, Dutta S, Bork U, Fritzmann J, Reissfelder C, Koch M, Weitz J (October 2011). "Invasion front-specific expression and prognostic significance of microRNA in colorectal liver metastases". Cancer Science. 102 (10): 1799–807. doi:10.1111/j.1349-7006.2011.02023.x. PMID 21722265.
- Xu L, Liang YN, Luo XQ, Liu XD, Guo HX (March 2011). "[Association of miRNAs expression profiles with prognosis and relapse in childhood acute lymphoblastic leukemia]". Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi. 32 (3): 178–81. PMID 21535956.
- Te JL, Dozmorov IM, Guthridge JM, Nguyen KL, Cavett JW, Kelly JA, Bruner GR, Harley JB, Ojwang JO (May 2010). Means T (ed.). "Identification of unique microRNA signature associated with lupus nephritis". PLOS ONE. 5 (5): e10344. Bibcode:2010PLoSO...510344T. doi:10.1371/journal.pone.0010344. PMC 2867940. PMID 20485490.
- Liu X, Wang T, Wakita T, Yang W (March 2010). "Systematic identification of microRNA and messenger RNA profiles in hepatitis C virus-infected human hepatoma cells". Virology. 398 (1): 57–67. doi:10.1016/j.virol.2009.11.036. PMID 20006370.
- Maes OC, Sarojini H, Wang E (October 2009). "Stepwise up-regulation of microRNA expression levels from replicating to reversible and irreversible growth arrest states in WI-38 human fibroblasts". Journal of Cellular Physiology. 221 (1): 109–19. doi:10.1002/jcp.21834. PMID 19475566. S2CID 21566082.
- Tanaka M, Oikawa K, Takanashi M, Kudo M, Ohyashiki J, Ohyashiki K, Kuroda M (2009). Jones C (ed.). "Down-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients". PLOS ONE. 4 (5): e5532. Bibcode:2009PLoSO...4.5532T. doi:10.1371/journal.pone.0005532. PMC 2678255. PMID 19440243.
External links
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