Mir-638 microRNA precursor family

In molecular biology mir-638 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

mir-638
Identifiers
Symbolmir-638
RfamRF00978
miRBase familyMIPF0000486
Other data
RNA typemicroRNA
Domain(s)Eukaryota;
PDB structuresPDBe

Expression in lupus nephritis

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miR-638 has been implicated in the pathogenesis of lupus nephritis (LN), with intra-renal expression levels differing between normal and lupus nephritis patients.[1] The degree of difference in expression levels further correlates with the degree of disease severity in each LN patient.

miR-638 and gastric cancer

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miR-638 levels are significantly downregulated in gastric cancer cell lines, along with deregulation of 23 other miRNAs.[2] Thus miR-628 is likely to be involved in the development and progression of gastric cancer.

Further applications

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miR-638 has additionally been found to be upregulated in the K562 leukaemic cell line.[3]

See also

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References

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  1. ^ Lu J, Kwan BC, Lai FM, Tam LS, Li EK, Chow KM, Wang G, Li PK, Szeto CC (May 2012). "Glomerular and tubulointerstitial miR-638, miR-198 and miR-146a expression in lupus nephritis". Nephrology. 17 (4): 346–51. doi:10.1111/j.1440-1797.2012.01573.x. PMID 22295894. S2CID 24163790.
  2. ^ Yao Y, Suo AL, Li ZF, Liu LY, Tian T, Ni L, Zhang WG, Nan KJ, Song TS, Huang C (2009). "MicroRNA profiling of human gastric cancer". Molecular Medicine Reports. 2 (6): 963–70. doi:10.3892/mmr_00000199. PMID 21475928.
  3. ^ Yang Y, Wang LL, Li YH, Gao XN, Yu L (April 2011). "[Expression level of miRNA-663 in different leukemic cell lines and its biological function]". Zhongguo Shi Yan Xue Ye Xue Za Zhi. 19 (2): 279–83. PMID 21518471.

Further reading

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