In molecular biology mir-652 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms, with expression levels of miRNAs and respective target mRNAs negatively correlated.
| mir-652 | |
|---|---|
| Identifiers | |
| Symbol | mir-652 |
| Rfam | RF00872 |
| miRBase family | MIPF0000333 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
Lineage
editmiR-652 expression is specific to cells of the myeloid lineage, in this instance to monocytes and granulocytes.[1]
miR-652 and liver cirrhosis
editmiR-652 serum levels are significantly altered in alcoholic- or hepatitis-C-induced liver cirrhosis patients. They have been found to be down-regulated in the circulating monocytes of such patients, thus supporting the idea of an miR-652 role in the mediation of fibrogenic and inflammatory processes in the pathogenesis of liver cirrhosis.[2]
Expression in liver cancer
editCirculating levels of miR-652 show gradual elevation with progression of liver cancer, as is also the case with miRNAs let-7a, let-7f, miR-34a, miR-98, miR-331 and miR-338.[3]
See also
editReferences
edit- ^ Allantaz F, Cheng DT, Bergauer T, Ravindran P, Rossier MF, Ebeling M, et al. (2012). "Expression profiling of human immune cell subsets identifies miRNA-mRNA regulatory relationships correlated with cell type specific expression". PLOS ONE. 7 (1): e29979. Bibcode:2012PLoSO...729979A. doi:10.1371/journal.pone.0029979. PMC 3262799. PMID 22276136.
- ^ Roderburg C, Mollnow T, Bongaerts B, Elfimova N, Vargas Cardenas D, Berger K, et al. (2012). "Micro-RNA profiling in human serum reveals compartment-specific roles of miR-571 and miR-652 in liver cirrhosis". PLOS ONE. 7 (3): e32999. Bibcode:2012PLoSO...732999R. doi:10.1371/journal.pone.0032999. PMC 3296762. PMID 22412969.
- ^ Sukata T, Sumida K, Kushida M, Ogata K, Miyata K, Yabushita S, Uwagawa S (January 2011). "Circulating microRNAs, possible indicators of progress of rat hepatocarcinogenesis from early stages". Toxicology Letters. 200 (1–2): 46–52. doi:10.1016/j.toxlet.2010.10.013. PMID 21035526.
Further reading
edit- Lulla RR, Costa FF, Bischof JM, Chou PM, de F Bonaldo M, Vanin EF, Soares MB (2011). "Identification of Differentially Expressed MicroRNAs in Osteosarcoma". Sarcoma. 2011: 732690. doi:10.1155/2011/732690. PMC 3140035. PMID 21789031.
- Lai CY, Yu SL, Hsieh MH, Chen CH, Chen HY, Wen CC, Huang YH, Hsiao PC, Hsiao CK, Liu CM, Yang PC, Hwu HG, Chen WJ (2011). Uddin M (ed.). "MicroRNA expression aberration as potential peripheral blood biomarkers for schizophrenia". PLOS ONE. 6 (6): e21635. Bibcode:2011PLoSO...621635L. doi:10.1371/journal.pone.0021635. PMC 3126851. PMID 21738743.
- Santarelli DM, Beveridge NJ, Tooney PA, Cairns MJ (January 2011). "Upregulation of dicer and microRNA expression in the dorsolateral prefrontal cortex Brodmann area 46 in schizophrenia". Biological Psychiatry. 69 (2): 180–7. doi:10.1016/j.biopsych.2010.09.030. hdl:1959.13/934011. PMID 21111402. S2CID 33340677.
- Gao W, Shen H, Liu L, Xu J, Xu J, Shu Y (April 2011). "MiR-21 overexpression in human primary squamous cell lung carcinoma is associated with poor patient prognosis". Journal of Cancer Research and Clinical Oncology. 137 (4): 557–66. doi:10.1007/s00432-010-0918-4. PMID 20508945. S2CID 5744114.
External links
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