In molecular biology mir-671 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
| mir-671 | |
|---|---|
| Identifiers | |
| Symbol | mir-671 |
| Rfam | RF00891 |
| miRBase family | MIPF0000358 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
Alcoholic and Non-Alcoholic Fatty Liver Disease
editmiR-671 expression levels have been found to be vary significantly between the alcoholic and non-alcoholic forms of fatty liver disease.[1]
CDR1 regulation
editmiR-671 has been seen to negatively regulate the CDR1 (Cerebellar Degeneration-Related protein 1) gene, through the targeting and cleavage of a circular antisense transcript of the CDR1 locus. There is a partnered decrease in CDR1 mRNA levels with this downregulation.[2]
FN1 repression
editmiR-671 is able to bind to and repress fibronection type 1 (FN1) mRNA at its 3'untranslated region binding site.[3]
See also
editReferences
edit- ^ Estep M, Armistead D, Hossain N, Elarainy H, Goodman Z, Baranova A, et al. (2010). "Differential expression of miRNAs in the visceral adipose tissue of patients with non-alcoholic fatty liver disease". Aliment Pharmacol Ther. 32 (3): 487–97. doi:10.1111/j.1365-2036.2010.04366.x. PMID 20497147.
- ^ Hansen TB, Wiklund ED, Bramsen JB, Villadsen SB, Statham AL, Clark SJ, et al. (2011). "miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA". EMBO J. 30 (21): 4414–22. doi:10.1038/emboj.2011.359. PMC 3230379. PMID 21964070.
- ^ Rutnam ZJ, Yang BB (2012). "The non-coding 3' UTR of CD44 induces metastasis by regulating extracellular matrix functions". J Cell Sci. 125 (Pt 8): 2075–85. doi:10.1242/jcs100818. PMID 22637644.
Further reading
edit- Hou, Q.; Huang, J.; Ju, Z.; Li, Q.; Li, L.; Wang, C.; Sun, T.; Wang, L.; Hou, M.; Hang, S.; Zhong, J. (2012). "Identification of Splice Variants, Targeted MicroRNAs and Functional Single Nucleotide Polymorphisms of theBOLA-DQA2Gene in Dairy Cattle". DNA and Cell Biology. 31 (5): 739–744. doi:10.1089/dna.2011.1402. PMC 3358092. PMID 22084936.
External links
edit
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