In molecular biology mir-675 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
| mir-675 | |
|---|---|
| Identifiers | |
| Symbol | mir-675 |
| Rfam | RF00897 |
| miRBase family | MIPF0000365 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
Inhibition of cell proliferation
editmiR-675 overexpression brings about reduced proliferation in a range of embryonic and extraembryonic stem cell lines. It has been found to be embedded in the first exon of the large intergenic non-coding RNA H19, which is responsible for limiting placental growth prior to birth. There is upregulation of the targets of miR-675 in placentas lacking H19; these include the insulin-like growth factor 1 receptor (IGF1R). Thus placentas lacking miR-675 continue to grow. It is possible that controlled miR-675 release from H19 may enable a rapid inhibition of cell proliferation in response to cellular stress or oncogenic signals.[1]
COL2A1 upregulation in Osteoarthritis
editmiR-675 has been found to be upregulated in osteoarthritic cartilage, alongside H19.[2] Indeed, there is co-regulation of these two RNAs. The COL2A1 gene associated with osteoarthritis through altered expression levels compared with in normal tissue is upregulated by miR-675 overexpression. It has been proposed that miR-675 may modulate collagen type II levels via an unknown target molecule, and there is potential for a diagnostic metabolic balance indicator in osteoarthritis through this microRNA.
See also
editReferences
edit- ^ Keniry A, Oxley D, Monnier P, Kyba M, Dandolo L, Smits G, Reik W (June 2012). "The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r". Nature Cell Biology. 14 (7): 659–65. doi:10.1038/ncb2521. PMC 3389517. PMID 22684254.
- ^ Steck E, Boeuf S, Gabler J, Werth N, Schnatzer P, Diederichs S, Richter W (October 2012). "Regulation of H19 and its encoded microRNA-675 in osteoarthritis and under anabolic and catabolic in vitro conditions". Journal of Molecular Medicine. 90 (10): 1185–95. doi:10.1007/s00109-012-0895-y. PMID 22527881. S2CID 14203960.
Further reading
edit- Xiao W, Bao ZX, Zhang CY, Zhang XY, Shi LJ, Zhou ZT, Jiang WW (2012). Lo KW (ed.). "Upregulation of miR-31* is negatively associated with recurrent/newly formed oral leukoplakia". PLOS ONE. 7 (6): e38648. Bibcode:2012PLoSO...738648X. doi:10.1371/journal.pone.0038648. PMC 3377716. PMID 22719913.
- Lu TX, Sherrill JD, Wen T, Plassard AJ, Besse JA, Abonia JP, Franciosi JP, Putnam PE, Eby M, Martin LJ, Aronow BJ, Rothenberg ME (April 2012). "MicroRNA signature in patients with eosinophilic esophagitis, reversibility with glucocorticoids, and assessment as disease biomarkers". The Journal of Allergy and Clinical Immunology. 129 (4): 1064–75.e9. doi:10.1016/j.jaci.2012.01.060. PMC 3466056. PMID 22391115.
- Martinez-Sanchez A, Dudek KA, Murphy CL (January 2012). "Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145)". The Journal of Biological Chemistry. 287 (2): 916–24. doi:10.1074/jbc.M111.302430. PMC 3256897. PMID 22102413.
- Schmitz KJ, Helwig J, Bertram S, Sheu SY, Suttorp AC, Seggewiss J, Willscher E, Walz MK, Worm K, Schmid KW (June 2011). "Differential expression of microRNA-675, microRNA-139-3p and microRNA-335 in benign and malignant adrenocortical tumours". Journal of Clinical Pathology. 64 (6): 529–35. doi:10.1136/jcp.2010.085621. PMC 3099361. PMID 21471143.
- Dudek KA, Lafont JE, Martinez-Sanchez A, Murphy CL (August 2010). "Type II collagen expression is regulated by tissue-specific miR-675 in human articular chondrocytes". The Journal of Biological Chemistry. 285 (32): 24381–7. doi:10.1074/jbc.M110.111328. PMC 2915673. PMID 20529846.
- Tsang WP, Ng EK, Ng SS, Jin H, Yu J, Sung JJ, Kwok TT (March 2010). "Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer". Carcinogenesis. 31 (3): 350–8. doi:10.1093/carcin/bgp181. PMID 19926638.
- Smits G, Mungall AJ, Griffiths-Jones S, Smith P, Beury D, Matthews L, Rogers J, Pask AJ, Shaw G, VandeBerg JL, McCarrey JR, Renfree MB, Reik W, Dunham I (August 2008). "Conservation of the H19 noncoding RNA and H19-IGF2 imprinting mechanism in therians". Nature Genetics. 40 (8): 971–6. doi:10.1038/ng.168. PMID 18587395. S2CID 5204748.
External links
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