In molecular biology mir-765 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
| mir-765 | |
|---|---|
| Identifiers | |
| Symbol | mir-765 |
| Rfam | RF01027 |
| miRBase family | MIPF0000545 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
Traumatic Brain Injury
editmiR-765 has been identified as a diagnostic marker for traumatic brain injury (TBI), due to significantly elevated levels in the plasma of TBI patients. Furthermore, combination with either miR-16 or miR-92a allows extremely accurate distinction between TBI patients and healthy controls.[1]
miR-765 and pheochromocytomas
editIncreased miR-765 expression is observed in Von Hippel-Lindau disease compared with the sporadic benign forms of pheochromocytomas.[2] It has been linked to neuronal plasticity through the neurotrophic tyrosine kinase receptor type 3 (NTRK3) gene. A NTRK3 3'UTR variant, ss102661458, is located in a functional target site of miR-765 and is able to significantly affect miRNA-mediated NTRK3 regulation. Through this there is restoration of the altered gene expression by miR-765. NTRK3 is underexpressed with high or overexpressed levels of miR-765, thus pointing towards a possible involvement of this relationship in pheochromocytoma pathogenesis.[3]
See also
editReferences
edit- ^ Redell JB, Moore AN, Ward NH, Hergenroeder GW, Dash PK (2010). "Human traumatic brain injury alters plasma microRNA levels". J. Neurotrauma. 27 (12): 2147–56. doi:10.1089/neu.2010.1481. PMC 6468948. PMID 20883153.
- ^ Tömböl Z, Eder K, Kovács A, Szabó PM, Kulka J, Likó I, et al. (2010). "MicroRNA expression profiling in benign (sporadic and hereditary) and recurring adrenal pheochromocytomas". Mod. Pathol. 23 (12): 1583–95. doi:10.1038/modpathol.2010.164. PMID 20818339.
- ^ Muiños-Gimeno M, Guidi M, Kagerbauer B, Martín-Santos R, Navinés R, Alonso P, et al. (2009). "Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders". Hum. Mutat. 30 (7): 1062–71. doi:10.1002/humu.21005. hdl:10230/16310. PMID 19370765. S2CID 25590659.
Further reading
edit- Gu, H.; Li, H.; Zhang, L.; Luan, H.; Huang, T.; Wang, L.; Fan, Y.; Zhang, Y.; Liu, X.; Wang, W.; Yuan, Z. (2012). "Diagnostic role of microRNA expression profile in the serum of pregnant women with fetuses with neural tube defects". Journal of Neurochemistry. 122 (3): 641–649. doi:10.1111/j.1471-4159.2012.07812.x. PMID 22642222.
- Della Vittoria Scarpati, G.; Falcetta, F.; Carlomagno, C.; Ubezio, P.; Marchini, S.; De Stefano, A.; Singh, V. K.; d'Incalci, M.; De Placido, S.; Pepe, S. (2011). "A Specific miRNA Signature Correlates with Complete Pathological Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer". International Journal of Radiation Oncology, Biology, Physics. 83 (4): 1113–1119. doi:10.1016/j.ijrobp.2011.09.030. PMID 22172905.
- Guidi, M.; Muiños-Gimeno, M.; Kagerbauer, B.; Martí, E. L.; Estivill, X.; Espinosa-Parrilla, Y. (2010). "Overexpression of miR-128 specifically inhibits the truncated isoform of NTRK3 and upregulates BCL2 in SH-SY5Y neuroblastoma cells". BMC Molecular Biology. 11: 95. doi:10.1186/1471-2199-11-95. PMC 3019150. PMID 21143953.
External links
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