In molecular biology mir-873 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
| mir-873 | |
|---|---|
| Identifiers | |
| Symbol | mir-873 |
| Rfam | RF00910 |
| miRBase family | MIPF0000390 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
Dysmaculinisation in males
editSignificant miR-873 reductions have been observed in the brains of dysmasculinised second generation males following the introduction of prenatal stress factors. Sexual dimorphisms in the brain are altered and there is female-like expression of key neurodevelopment genes. The common target gene for miR-873, β-glycan, has increased expression.[1] It is thought that miR-873, along with other miRNAs, may play a role in organisation of the sexually dimorphic brain due to a marked response to organisational testosterone.
Chromatin remodelling
editmiR-873 is associated with translational regulation of factors involved in chromatin remodelling, and is downregulated by the human T-cell leukaemia virus type 1 (HTLV-1) transactivating protein, Tax.[2] Specifically, it has been found to directly target the chromatin remodelling factors p300 and p/CAF.
See also
editReferences
edit- ^ Morgan CP, Bale TL (2011). "Early prenatal stress epigenetically programs dysmasculinization in second-generation offspring via the paternal lineage". J Neurosci. 31 (33): 11748–55. doi:10.1523/JNEUROSCI.1887-11.2011. PMC 3164823. PMID 21849535.
- ^ Rahman S, Quann K, Pandya D, Singh S, Khan ZK, Jain P (2012). "HTLV-1 Tax mediated downregulation of miRNAs associated with chromatin remodeling factors in T cells with stably integrated viral promoter". PLOS ONE. 7 (4): e34490. Bibcode:2012PLoSO...734490R. doi:10.1371/journal.pone.0034490. PMC 3319589. PMID 22496815.
Further reading
edit- Skalsky, R. L.; Cullen, B. R. (2011). Borras, Consuelo (ed.). "Reduced Expression of Brain-Enriched microRNAs in Glioblastomas Permits Targeted Regulation of a Cell Death Gene". PLOS ONE. 6 (9): e24248. Bibcode:2011PLoSO...624248S. doi:10.1371/journal.pone.0024248. PMC 3166303. PMID 21912681.
- Xu, G.; Zhang, Y.; Jia, H.; Li, J.; Liu, X.; Engelhardt, J. F.; Wang, Y. (2009). "Cloning and identification of microRNAs in bovine alveolar macrophages". Molecular and Cellular Biochemistry. 332 (1–2): 9–16. doi:10.1007/s11010-009-0168-4. PMID 19507003. S2CID 10508574.
External links
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