Mitochondrial 2-oxoglutarate/malate carrier protein

SLC25A11
Identifiers
Aliases	SLC25A11, OGC, SLC20A4, solute carrier family 25 member 11, PGL6
External IDs	OMIM: 604165; MGI: 1915113; HomoloGene: 2637; GeneCards: SLC25A11; OMA:SLC25A11 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	4,940,053 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	70,538,305 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; muscle of thigh; ; right auricle; ; left ventricle; ; gastrocnemius muscle; ; body of tongue; ; mucosa of transverse colon; ; right frontal lobe; ; prefrontal cortex; ; Skeletal muscle tissue of rectus abdominis;
	Top expressed in
	extraocular muscle; ; right ventricle; ; interventricular septum; ; digastric muscle; ; myocardium of ventricle; ; plantaris muscle; ; cardiac muscle tissue of left ventricle; ; temporal muscle; ; muscle of thigh; ; sternocleidomastoid muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	RNA binding; oxoglutarate:malate antiporter activity; transmembrane transporter activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; mitochondrion; nucleus; mitochondrial inner membrane;
Biological process	gluconeogenesis; alpha-ketoglutarate transport; mitochondrial transport; transport; transmembrane transport; malate transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	8402
	67863
	ENSG00000108528
	ENSMUSG00000014606
	Q02978
	Q9CR62
	NM_003562; NM_001165417; NM_001165418
	NM_024211
	NP_001158889; NP_001158890; NP_003553
	NP_077173
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial 2-oxoglutarate/malate carrier protein is a protein that in humans is encoded by the SLC25A11 gene.^[5]^[6]^[7] Inactivating mutations in this gene predispose to metastasic paraganglioma.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000108528 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000014606 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Piccininni S, Iacobazzi V, Lauria G, Rocchi M, Palmieri F (Mar 1999). "Assignment of the oxoglutarate carrier gene (SLC20A4) to human chromosome 17p13.3". Cytogenet Cell Genet. 83 (3–4): 256–7. doi:10.1159/000015198. PMID 10072597. S2CID 36221506.
^ Iacobazzi V, Palmieri F, Runswick MJ, Walker JE (Jan 1993). "Sequences of the human and bovine genes for the mitochondrial 2-oxoglutarate carrier". DNA Seq. 3 (2): 79–88. doi:10.3109/10425179209034000. PMID 1457818.
^ "Entrez Gene: SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11".
^ Buffet A, Morin A, Castro-Vega LJ, Habarou F, Lussey-Lepoutre C, Letouzé E, Lefebvre H, Guilhem I, Magalie H (2018-02-05). "Germline mutations in the mitochondrial 2-oxoglutarate/malate carrier SLC25A11 gene confer a predisposition to metastatic paragangliomas". Cancer Research. 78 (8): 1914–1922. doi:10.1158/0008-5472.CAN-17-2463. ISSN 1538-7445. PMID 29431636.

Bisaccia F, Zara V, Capobianco L, et al. (1996). "The formation of a disulfide cross-link between the two subunits demonstrates the dimeric structure of the mitochondrial oxoglutarate carrier". Biochim. Biophys. Acta. 1292 (2): 281–88. doi:10.1016/0167-4838(95)00215-4. PMID 8597574.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Bisaccia F, Capobianco L, Mazzeo M, Palmieri F (1996). "The mitochondrial oxoglutarate carrier protein contains a disulfide bridge between intramembranous cysteines 221 and 224". FEBS Lett. 392 (1): 54–8. doi:10.1016/0014-5793(96)00784-3. PMID 8769314. S2CID 46276462.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Palmisano A, Zara V, Hönlinger A, et al. (1998). "Targeting and assembly of the oxoglutarate carrier: general principles for biogenesis of carrier proteins of the mitochondrial inner membrane". Biochem. J. 333 ( Pt 1) (Pt 1): 151–8. doi:10.1042/bj3330151. PMC 1219567. PMID 9639574.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Coll O, Colell A, García-Ruiz C, et al. (2003). "Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion". Hepatology. 38 (3): 692–702. doi:10.1053/jhep.2003.50351. hdl:10261/111821. PMID 12939596. S2CID 2128549.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kabe Y, Ohmori M, Shinouchi K, et al. (2006). "Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier". J. Biol. Chem. 281 (42): 31729–35. doi:10.1074/jbc.M604729200. PMID 16920706.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000108528 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000014606 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10072597-5] Piccininni S, Iacobazzi V, Lauria G, Rocchi M, Palmieri F (Mar 1999). "Assignment of the oxoglutarate carrier gene (SLC20A4) to human chromosome 17p13.3". Cytogenet Cell Genet. 83 (3–4): 256–7. doi:10.1159/000015198. PMID 10072597. S2CID 36221506.

[pmid1457818-6] Iacobazzi V, Palmieri F, Runswick MJ, Walker JE (Jan 1993). "Sequences of the human and bovine genes for the mitochondrial 2-oxoglutarate carrier". DNA Seq. 3 (2): 79–88. doi:10.3109/10425179209034000. PMID 1457818.

[entrez-7] "Entrez Gene: SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11".

[8] Buffet A, Morin A, Castro-Vega LJ, Habarou F, Lussey-Lepoutre C, Letouzé E, Lefebvre H, Guilhem I, Magalie H (2018-02-05). "Germline mutations in the mitochondrial 2-oxoglutarate/malate carrier SLC25A11 gene confer a predisposition to metastatic paragangliomas". Cancer Research. 78 (8): 1914–1922. doi:10.1158/0008-5472.CAN-17-2463. ISSN 1538-7445. PMID 29431636.

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Mitochondrial 2-oxoglutarate/malate carrier protein

See also

References

Further reading