Mitochondrial ribosomal protein L11

39S ribosomal protein L11, mitochondrial is a protein that in humans is encoded by the MRPL11 gene.

MRPL11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	MRPL11, L11MT, MRP-L11, CGI-113, mitochondrial ribosomal protein L11
External IDs	OMIM: 611826; MGI: 2137215; HomoloGene: 6768; GeneCards: MRPL11; OMA:MRPL11 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.2 Start 66,435,075 bp End 66,466,738 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 A Start 5,012,175 bp End 5,017,027 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon muscle of thigh apex of heart gastrocnemius muscle muscle layer of sigmoid colon right lobe of liver rectum right auricle left ventricle body of stomach Top expressed in condyle fossa motor neuron Paneth cell primitive streak internal carotid artery external carotid artery ascending aorta aortic valve medial ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function rRNA binding protein binding structural constituent of ribosome RNA binding large ribosomal subunit rRNA binding Cellular component mitochondrial inner membrane ribosome mitochondrial ribosome mitochondrion mitochondrial large ribosomal subunit large ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination ribosomal large subunit assembly protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 65003 66419 Ensembl ENSG00000174547 ENSMUSG00000024902 UniProt Q9Y3B7 Q9CQF0 RefSeq (mRNA) NM_016050 NM_170738 NM_170739 NM_025553 RefSeq (protein) NP_057134 NP_733934 NP_733935 NP_079829 Location (UCSC) Chr 11: 66.44 – 66.47 Mb Chr 19: 5.01 – 5.02 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode different isoforms. Pseudogenes corresponding to this gene are found on chromosomes 5q and 12q.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
• Suzuki T, Terasaki M, Takemoto-Hori C, et al. (2001). "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria". J. Biol. Chem. 276 (24): 21724–36. doi:10.1074/jbc.M100432200. PMID 11279069.
• Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
• Voronina EN, Kolokol'tsova TD, Nechaeva EA, Filipenko ML (2003). "[Structural and functional analysis of the human ribosomal protein L11 gene]". Mol. Biol. (Mosk.). 37 (3): 425–35. PMID 12815950.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Sun XX, Dai MS, Lu H (2007). "5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction". J. Biol. Chem. 282 (11): 8052–9. doi:10.1074/jbc.M610621200. PMID 17242401.