Mitochondrial ribosomal protein L33

39S ribosomal protein L33, mitochondrial is a protein that in humans is encoded by the MRPL33 gene.

MRPL33
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	MRPL33, C2orf1, L33mt, MRP-L33, RPL33L, mitochondrial ribosomal protein L33
External IDs	OMIM: 610059; MGI: 2137225; HomoloGene: 81733; GeneCards: MRPL33; OMA:MRPL33 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2p23.2 Start 27,771,717 bp End 27,988,087 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 B1 Start 31,754,279 bp End 31,821,728 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex left adrenal cortex gastrocnemius muscle left ventricle right auricle apex of heart biceps brachii popliteal artery tibial arteries thoracic aorta Top expressed in granulocyte yolk sac morula muscle of thigh atrioventricular valve intercostal muscle right kidney ventricular zone blastocyst endocardial cushion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome Cellular component mitochondrial inner membrane ribosome intracellular anatomical structure mitochondrion mitochondrial large ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9553 66845 Ensembl ENSG00000243147 ENSMUSG00000106918 UniProt O75394 Q9CQP0 RefSeq (mRNA) NM_145330 NM_004891 NM_025796 RefSeq (protein) NP_004882 NP_663303 NP_080072 Location (UCSC) Chr 2: 27.77 – 27.99 Mb Chr 5: 31.75 – 31.82 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described.

Further reading

• Zhang Z, Gerstein M (May 2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
• Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (September 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
• Suzuki T, Terasaki M, Takemoto-Hori C, Hanada T, Ueda T, Wada A, Watanabe K (June 2001). "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria". The Journal of Biological Chemistry. 276 (24): 21724–36. doi:10.1074/jbc.M100432200. PMID 11279069.
• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (July 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.

External links

• Overview of all the structural information available in the PDB for UniProt: O75394 (Human 39S ribosomal protein L33, mitochondrial (MRPL33)) at the PDBe-KB.