Mitochondrial ribosomal protein L41

39S ribosomal protein L41, mitochondrial is a protein that in humans is encoded by the MRPL41 gene.

MRPL41
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	MRPL41, BMRP, MRP-L27, MRPL27, RPML27, PIG3, Mitochondrial ribosomal protein L41
External IDs	OMIM: 611846; MGI: 1333816; HomoloGene: 13036; GeneCards: MRPL41; OMA:MRPL41 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q34.3 Start 137,551,879 bp End 137,552,555 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 A3 Start 24,864,129 bp End 24,865,110 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart myocardium of left ventricle right auricle right ventricle mucosa of transverse colon cingulate gyrus anterior cingulate cortex caudate nucleus putamen muscle of thigh Top expressed in facial motor nucleus fossa condyle motor neuron epithelium of lens endocardial cushion external carotid artery internal carotid artery renal corpuscle atrioventricular junction More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome protein binding RNA binding Cellular component mitochondrial inner membrane ribosome mitochondrion mitochondrial large ribosomal subunit ribonucleoprotein complex Biological process cell cycle mitochondrial translational elongation mitochondrial translational termination protein biosynthesis apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64975 107733 Ensembl ENSG00000182154 ENSMUSG00000036850 UniProt Q8IXM3 Q9CQN7 RefSeq (mRNA) NM_032477 NM_001031808 RefSeq (protein) NP_115866 NP_001026978 Location (UCSC) Chr 9: 137.55 – 137.55 Mb Chr 2: 24.86 – 24.87 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family.

Further reading

• Goldschmidt-Reisin S, Kitakawa M, Herfurth E, et al. (1999). "Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences". J. Biol. Chem. 273 (52): 34828–36. doi:10.1074/jbc.273.52.34828. PMID 9857009.
• Koc EC, Burkhart W, Blackburn K, et al. (2001). "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present". J. Biol. Chem. 276 (47): 43958–69. doi:10.1074/jbc.M106510200. PMID 11551941.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Chintharlapalli SR, Jasti M, Malladi S, et al. (2005). "BMRP is a Bcl-2 binding protein that induces apoptosis". J. Cell. Biochem. 94 (3): 611–26. doi:10.1002/jcb.20292. PMID 15547950. S2CID 23940695.
• Yoo YA, Kim MJ, Park JK, et al. (2005). "Mitochondrial ribosomal protein L41 suppresses cell growth in association with p53 and p27Kip1". Mol. Cell. Biol. 25 (15): 6603–16. doi:10.1128/MCB.25.15.6603-6616.2005. PMC 1190350. PMID 16024796.
• Kim MJ, Yoo YA, Kim HJ, et al. (2006). "Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21(WAF1/CIP1)". Biochem. Biophys. Res. Commun. 338 (2): 1179–84. doi:10.1016/j.bbrc.2005.10.064. PMID 16256947.