Both Northern blot analysis and inspection of the human expressed sequence tag (EST) database suggest relatively little expression of MCT2 in human tissues. As well, the sequence of MCT2 is far less conserved across species than that of MCT1 or MCT4 and there also appear to be considerable species differences in the tissue expression profile of this isoform.
Of the four known mammalian lactate transporters (MCTs 1-4), MCT2 harbors the highest affinity for lactate.[6] In parallel, MCT2 gene transcription has been demonstrated to respond with high-sensitivity to hypoxia, intracellular pH, and, to lactate.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS (Apr 1994). "Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle". Cell. 76 (5): 865–73. doi:10.1016/0092-8674(94)90361-1. PMID8124722. S2CID22137883.
^Halestrap AP (Jan 2012). "The monocarboxylate transporter family--Structure and functional characterization". IUBMB Life. 64 (1): 1–9. doi:10.1002/iub.573. PMID22131303. S2CID24460891.
Halestrap AP (2012). "The monocarboxylate transporter family--Structure and functional characterization". IUBMB Life. 64 (1): 1–9. doi:10.1002/iub.573. PMID22131303. S2CID24460891.
