Morgaine may refer to:
- Morgaine, alternative name for Morgan le Fay in original legends and some modern adaptations such as The Mists of Avalon
- Morgaine, heroine of The Morgaine Stories by C. J. Cherryh
- Morgaine le Fey (DC Comics), a character inspired by the legendary figure
- Morgaine, a sorceress in the Doctor Who serial Battlefield