Mubritinib

Mubritinib
Clinical data
Routes of; administration	Oral
ATC code	none;
Legal status
Legal status	In general: uncontrolled;
Identifiers
	IUPAC name 1-(4-{4-[(2-{(E)-2-[4-(trifluoromethyl)phenyl]ethenyl}-1,3-oxazol-4-yl)methoxy]phenyl}butyl)-1H-1,2,3-triazole;
CAS Number	366017-09-6;
PubChem CID	6444692;
IUPHAR/BPS	6011;
ChemSpider	4948554;
UNII	V734AZP9BR;
ChEMBL	ChEMBL1614707;
CompTox Dashboard (EPA)	DTXSID501026014 ;
Chemical and physical data
Formula	C25H23F3N4O2
Molar mass	468.480 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES FC(F)(F)c1ccc(cc1)\C=C\c2nc(co2)COc3ccc(cc3)CCCCn4nncc4;
	InChI InChI=1S/C25H23F3N4O2/c26-25(27,28)21-9-4-20(5-10-21)8-13-24-30-22(18-34-24)17-33-23-11-6-19(7-12-23)3-1-2-15-32-16-14-29-31-32/h4-14,16,18H,1-3,15,17H2/b13-8+; Key:ZTFBIUXIQYRUNT-MDWZMJQESA-N;

Mubritinib (TAK-165) is a protein kinase inhibitor which was under development by Takeda for the treatment of cancer.^[1]^[2]^[3] It completed phase I clinical trials but appears to have been discontinued, as no new information on the drug has surfaced since December 2008.^[4]

References

^ McCormick F, Fabbro D (2005). Protein Tyrosine Kinases: From Inhibitors to Useful Drugs (Cancer Drug Discovery and Development). Totowa, NJ: Humana Press. doi:10.1385/1-59259-962-1:001. ISBN 1-58829-384-X.
^ Mitscher LA, Lednicer D (1977). The organic chemistry of drug synthesis. New York: Wiley. ISBN 0-470-10750-2.
^ Lednicer D (2008). Strategies for Organic Drug Synthesis and Design. New York: Wiley-Interscience. ISBN 978-0-470-19039-5.
^ Clinical trial number NCT00034281 for "Safety and Tolerability Study of TAK-165 in Subjects With Tumors Expressing HER2" at ClinicalTrials.gov

[isbn1-58829-384-X-1] McCormick F, Fabbro D (2005). Protein Tyrosine Kinases: From Inhibitors to Useful Drugs (Cancer Drug Discovery and Development). Totowa, NJ: Humana Press. doi:10.1385/1-59259-962-1:001. ISBN 1-58829-384-X.

[isbn0-470-10750-2-2] Mitscher LA, Lednicer D (1977). The organic chemistry of drug synthesis. New York: Wiley. ISBN 0-470-10750-2.

[isbn0-470-19039-6-3] Lednicer D (2008). Strategies for Organic Drug Synthesis and Design. New York: Wiley-Interscience. ISBN 978-0-470-19039-5.

[urlSafety_and_Tolerability_Study_of_TAK-165_in_Subjects_With_Tumors_Expressing_HER2_-_Full_Text_View_-_ClinicalTrials.gov-4] Clinical trial number NCT00034281 for "Safety and Tolerability Study of TAK-165 in Subjects With Tumors Expressing HER2" at ClinicalTrials.gov

[1]

[2]

[3]

[4]

Clinical data

Routes of administration	Oral
ATC code	none
Legal status
Legal status	In general: uncontrolled
Identifiers
IUPAC name 1-(4-{4-[(2-{(E)-2-[4-(trifluoromethyl)phenyl]ethenyl}-1,3-oxazol-4-yl)methoxy]phenyl}butyl)-1H-1,2,3-triazole
CAS Number	366017-09-6
PubChem CID	6444692
IUPHAR/BPS	6011
ChemSpider	4948554
UNII	V734AZP9BR
ChEMBL	ChEMBL1614707
CompTox Dashboard (EPA)	DTXSID501026014
Chemical and physical data
Formula	C₂₅H₂₃F₃N₄O₂
Molar mass	468.480 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES FC(F)(F)c1ccc(cc1)\C=C\c2nc(co2)COc3ccc(cc3)CCCCn4nncc4
InChI InChI=1S/C25H23F3N4O2/c26-25(27,28)21-9-4-20(5-10-21)8-13-24-30-22(18-34-24)17-33-23-11-6-19(7-12-23)3-1-2-15-32-16-14-29-31-32/h4-14,16,18H,1-3,15,17H2/b13-8+ Key:ZTFBIUXIQYRUNT-MDWZMJQESA-N

Mubritinib

See also

References