Muguruza is a Basque surname. Notable people with the surname include:
- Fermin Muguruza, Spanish rock musician, singer, songwriter, producer, and record label manager
- Garbiñe Muguruza (born 1993), Spanish-Venezuelan tennis player
- Joseba Muguruza, Spanish footballer
- Josu Muguruza (1958–1989), Basque-origin Spanish journalist and politician