Mulroney is a surname of Irish origin. Notable people with the surname include:
- Mulroney family
- Brian Mulroney (1939–2024), Prime Minister of Canada 1984–1993
- Mila Mulroney (born 1953), wife of Brian Mulroney
- Caroline Mulroney (born 1974), daughter of Brian Mulroney; Ontario cabinet minister
- Ben Mulroney (born 1976), son of Brian Mulroney; Canadian television host
- Brian Mulroney (1939–2024), Prime Minister of Canada 1984–1993
- Dermot Mulroney (born 1963), American actor
- Kieran Mulroney (born 1965), American television actor and musician