Multidrug and toxin extrusion protein 1

Multidrug and toxin extrusion protein 1 (MATE1), also known as solute carrier family 47 member 1, is a protein that in humans is encoded by the SLC47A1 gene. SLC47A1 belongs to the MATE (multidrug and toxic compound extrusion) family of transporters that are found in bacteria, archaea and eukaryotes.

SLC47A1
Identifiers
Aliases	SLC47A1, MATE1, solute carrier family 47 member 1
External IDs	OMIM: 609832; MGI: 1914723; HomoloGene: 34364; GeneCards: SLC47A1; OMA:SLC47A1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17p11.2 Start 19,495,385 bp End 19,579,034 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B2 Start 61,234,227 bp End 61,269,171 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex kidney tubule left adrenal cortex glomerulus metanephric glomerulus right lobe of liver human kidney canal of the cervix gastrocnemius muscle gonad Top expressed in proximal tubule right kidney human kidney left lobe of liver lumbar spinal ganglion interventricular septum myocardium of ventricle cardiac muscles extraocular muscle digastric muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function antiporter activity monovalent cation:proton antiporter activity xenobiotic transmembrane transporter activity Cellular component integral component of membrane plasma membrane membrane vesicle Biological process proton transmembrane transport transmembrane transport xenobiotic export xenobiotic transmembrane transport organic cation transport cation transport xenobiotic transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55244 67473 Ensembl ENSG00000142494 ENSMUSG00000010122 UniProt Q96FL8 Q8K0H1 RefSeq (mRNA) NM_018242 NM_026183 RefSeq (protein) NP_060712 NP_080459 Location (UCSC) Chr 17: 19.5 – 19.58 Mb Chr 11: 61.23 – 61.27 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Gene

The SLC47A1 gene is located within the Smith–Magenis syndrome region on chromosome 17.

Function

SLC47A1 is a member of the MATE family of transporters that excrete endogenous and exogenous toxic electrolytes through urine and bile.

Discovery

The multidrug efflux transporter NorM from V. parahaemolyticus which mediates resistance to multiple antimicrobial agents (norfloxacin, kanamycin, ethidium bromide etc.) and its homologue from E. coli were identified in 1998, which is the first of Solute carrier family 47 member. NorM seems to function as drug/sodium antiporter which is the first example of Na⁺-coupled multidrug efflux transporter. NorM is a prototype of a new transporter family and Brown et al. named it the multidrug and toxic compound extrusion family. The X-ray structure of the transporter NorM was determined to 3.65 Å, revealing an outward-facing conformation with two portals open to the outer leaflet of the membrane and a unique topology of the predicted 12 transmembrane helices distinct from any other known multidrug resistance transporter.

See also

• MATE (Multi antimicrobial extrusion protein or multidrug and toxic compound extrusion protein)

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Bi W, Yan J, Stankiewicz P, et al. (2002). "Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse". Genome Res. 12 (5): 713–28. doi:10.1101/gr.73702. PMC 186594. PMID 11997338.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Otsuka M, Matsumoto T, Morimoto R, et al. (2006). "A human transporter protein that mediates the final excretion step for toxic organic cations". Proc. Natl. Acad. Sci. U.S.A. 102 (50): 17923–8. doi:10.1073/pnas.0506483102. PMC 1312386. PMID 16330770.
• Ohta KY, Inoue K, Hayashi Y, Yuasa H (2006). "Molecular identification and functional characterization of rat multidrug and toxin extrusion type transporter 1 as an organic cation/H+ antiporter in the kidney". Drug Metab. Dispos. 34 (11): 1868–74. doi:10.1124/dmd.106.010876. PMID 16928787. S2CID 7746302.
• Omote H, Hiasa M, Matsumoto T, et al. (2007). "The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations". Trends Pharmacol. Sci. 27 (11): 587–93. doi:10.1016/j.tips.2006.09.001. PMID 16996621.
• Tsuda M, Terada T, Asaka J, et al. (2007). "Oppositely directed H+ gradient functions as a driving force of rat H+/organic cation antiporter MATE1". Am. J. Physiol. Renal Physiol. 292 (2): F593–8. doi:10.1152/ajprenal.00312.2006. PMID 17047166. S2CID 15246627.
• Chen Y, Zhang S, Sorani M, Giacomini KM (2007). "Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family". J. Pharmacol. Exp. Ther. 322 (2): 695–700. doi:10.1124/jpet.107.123554. PMID 17495125. S2CID 17580413.
• Tanihara Y, Masuda S, Sato T, et al. (2007). "Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters". Biochem. Pharmacol. 74 (2): 359–71. doi:10.1016/j.bcp.2007.04.010. hdl:2433/124277. PMID 17509534.
• Kajiwara M, Terada T, Asaka J, et al. (2007). "Critical roles of Sp1 in gene expression of human and rat H+/organic cation antiporter MATE1". Am. J. Physiol. Renal Physiol. 293 (5): F1564–70. doi:10.1152/ajprenal.00322.2007. PMID 17855482. S2CID 46209703.