Munthali is an East African surname. Notable people with this surname include:
- Mwiza Munthali, Malawian-born activist and specialist in Africa and African Diaspora affairs
- Brighton Munthali (born 1997), Malawian professional footballer
- Rumba Munthali (born 1978), Zambi-Canadian former professional soccer player
- Francis Munthali, Malawian former middle-distance runner
- Christopher Munthali, Zambian professional footballer