Mustafin (Russian: Мустафин) is a Bashkir, Tatar and Uzbek masculine surname, which is common in the countries of the former Soviet Union; its feminine counterpart is Mustafina. It may refer to:
- Aliya Mustafina (born 1994), Russian artistic gymnast
- Farhat Mustafin (born 1950), Russian wrestler
- Gabiden Mustafin (1902–1984), Kazakh author and politician
- Isaac Mustafin (1908–1968), Russian chemist
- Mikhail Mustafin (born 1983), Russian football player
- Oleksiy Mustafin (born 1971), Ukrainian media manager, journalist, and politician
- Rifat Mustafin (born 1983), Russian football player
- Rustam Mustafin (born 1977), Russian football player
- Temur Mustafin (born 1995), Russian football player