Muzolimine is a high-ceiling loop diuretic.[1] It is a pyrazole diuretic which was used for treatment of hypertension but was withdrawn worldwide because of severe neurological side effects.[2]
 | |
| Clinical data | |
|---|---|
| ATC code | |
| Legal status | |
| Legal status |
|
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| KEGG | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.054.139 |
| Chemical and physical data | |
| Formula | C11H11Cl2N3O |
| Molar mass | 272.13 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
  (what is this?) (verify) | |
Synthesis
edit
Rxn of (1-(3,4-dichlorophenyl)ethyl)hydrazine (1) with ethyl 3-amino-3-ethoxyacrylate (2) leads to a ring-forming two-site reaction and formation of the pyrazoline diuretic agent, muzolimine (3).
References
edit- ^ Wangemann P, Braitsch R, Greger R (December 1987). "The diuretic effect of muzolimine". Pflügers Archiv. 410 (6): 674–6. doi:10.1007/BF00581331. PMID 3449804. S2CID 19367481.
- ^ Reyes AJ, Leary WP (January 1993). "Clinicopharmacological reappraisal of the potency of diuretics". Cardiovascular Drugs and Therapy. 7 Suppl 1: 23–8. doi:10.1007/BF00877955. PMID 8435374. S2CID 29589710.
- ^ DE 2319278, Möller, Eike; Meng, Karl & Wehinger, Egbert et al., "Diuretisches und antihypertensives Mitel [Diuretic and antihypertensive agent]", published 1974-11-07, assigned to Bayer AG
- ^ E. Möller et al., U.S. patent 3,957,814 (1976 to Bayer); eidem, Experientia 33, 382 (1977).
 | This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it. |