N-Succinimidyl 4-fluorobenzoate

N-Succinimidyl 4-fluorobenzoate (SFB) is an organofluorine compound. When incorporating a fluorine-18 atom, SFB is used to label proteins or peptides for positron emission tomography.[1]

N-Succinimidyl 4-fluorobenzoate
Names
Preferred IUPAC name
2,5-Dioxopyrrolidin-1-yl 4-fluorobenzoate
Other names
SFB
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/C11H8FNO4/c12-8-3-1-7(2-4-8)11(16)17-13-9(14)5-6-10(13)15/h1-4H,5-6H2 checkY
    Key: LSSQMISUDUUZCC-UHFFFAOYSA-N checkY
  • FC1=CC=C(C(ON2C(CCC2=O)=O)=O)C=C1
  • 18F: C1CC(=O)N(C1=O)OC(=O)C2=CC=C(C=C2)[18F]
Properties
C11H8FNO4
Molar mass 237.186 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

References

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  1. ^ Vaidyanathan, G; Zalutsky, MR (1992). "Labeling proteins with fluorine-18 using N-succinimidyl 4-[18F]fluorobenzoate". International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology. 19 (3): 275–81. doi:10.1016/0883-2897(92)90111-b. PMID 1629016.