N-myc-interactor also known as N-myc and STAT interactor is a protein that in humans is encoded by the NMI gene.[5][6][7]

NMI
Identifiers
AliasesNMI, N-myc and STAT interactor
External IDsOMIM: 603525; MGI: 1928368; HomoloGene: 3441; GeneCards: NMI; OMA:NMI - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004688

NM_001141948
NM_001141949
NM_019401

RefSeq (protein)

NP_004679

NP_001135420
NP_001135421
NP_062274

Location (UCSC)Chr 2: 151.27 – 151.29 MbChr 2: 51.84 – 51.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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NMYC interactor (NMI) interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL-2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias.[7]

Interactions

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NMI (gene) has been shown to interact with BRCA1,[8] IFI35,[9] Myc,[8] and STAT5A,[6] and TUBA3C.[10]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123609Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026946Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bao J, Zervos AS (Aug 1996). "Isolation and characterization of Nmi, a novel partner of Myc proteins". Oncogene. 12 (10): 2171–6. PMID 8668343.
  6. ^ a b Zhu M, John S, Berg M, Leonard WJ (Mar 1999). "Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling". Cell. 96 (1): 121–30. doi:10.1016/S0092-8674(00)80965-4. PMID 9989503. S2CID 14758136.
  7. ^ a b "Entrez Gene: NMI N-myc (and STAT) interactor".
  8. ^ a b Li H, Lee TH, Avraham H (June 2002). "A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer". J. Biol. Chem. 277 (23): 20965–73. doi:10.1074/jbc.M112231200. PMID 11916966.
  9. ^ Chen J, Shpall RL, Meyerdierks A, Hagemeier M, Böttger EC, Naumovski L (November 2000). "Interferon-inducible Myc/STAT-interacting protein Nmi associates with IFP 35 into a high molecular mass complex and inhibits proteasome-mediated degradation of IFP 35". J. Biol. Chem. 275 (46): 36278–84. doi:10.1074/jbc.M006975200. PMID 10950963.
  10. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading

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