N-nucleotides, or nontemplated nucleotides are believed to exist only to create diversity at V(D)J junctions (see V(D)J recombination) during lymphocyte development.[1] The addition of these nucleotides is aided by an enzyme called Terminal deoxynucleotidyl transferase (TdT)
References
edit- ^ Sandor, Z; Calicchio, ML; Sargent, RG; Roth, DB; Wilson, JH (2004). "Distinct requirements for Ku in N nucleotide addition at V(D)J- and non-V(D)J-generated double-strand breaks". Nucleic Acids Res. 32 (6): 1866–73. doi:10.1093/nar/gkh502. PMC 390357. PMID 15047854.