N1-Methyl-4-pyridone-3-carboxamide, also abbreviated as 4PY, is a breakdown product of niacin,[1] that is associated with an increased risk of cardiovascular disease.[2] It has 2 carbonyl groups that are close to each other.[3][4][5]
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| Names | |
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| IUPAC name
1-Methyl-4-oxopyridine-3-carboxamide
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| Other names
4PY
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| Identifiers | |
3D model (JSmol)
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PubChem CID
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CompTox Dashboard (EPA)
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| Properties | |
| C7H8N2O2 | |
| Molar mass | 152.153 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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References
edit- ^ Cosmetic Ingredient Review Expert Panel (2005). "Final report of the safety assessment of niacinamide and niacin". International Journal of Toxicology. 24 (Suppl 5): 1–31. doi:10.1080/10915810500434183. PMID 16596767. S2CID 208149068.
- ^ Ferrell M, Wang Z, Anderson JT, Li XS, Witkowski M, DiDonato JA, Hilser JR, Hartiala JA, Haghikia A, Cajka T, Fiehn O, Sangwan N, Demuth I, König M, Steinhagen-Thiessen E, Landmesser U, Tang WH, Allayee H, Hazen SL (February 2024). "A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk". Nature Medicine. 30 (2): 424–434. doi:10.1038/s41591-023-02793-8. PMID 38374343.
- ^ "Cleveland Clinic-Led Study Discovers Link between High Levels of Niacin – a Common B Vitamin – and Heart Disease". 19 February 2024.
- ^ "N1-Methyl-4-pyridone-3-carboxamide". Toxin and Toxin Target Database (T3DB). T3D4179.
- ^ MasterJohn C (24 February 2024). "NMN Probably Won't Make You Live Forever". Substack.
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