NADPH:quinone reductase

In enzymology, a NADPH:quinone reductase (EC 1.6.5.5) is an enzyme that catalyzes the chemical reaction

NADPH:quinone reductase
Identifiers
EC no.1.6.5.5
CAS no.9032-20-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
NADPH + H+ + 2quinone NADP+ + 2semiquinone

The 3 substrates of this enzyme are NADPH, H+, and quinone, whereas its two products are NADP+ and semiquinone.

This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with a quinone or similar compound as acceptor. The systematic name of this enzyme class is NADPH:quinone oxidoreductase. This enzyme is also called NADPH2:quinone reductase.

Structural studies

edit

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1IYZ, 1IZ0, and 1YB5.

References

edit
  • Rao PV, Krishna CM, Zigler JS Jr (1992). "Identification and characterization of the enzymatic activity of zeta-crystallin from guinea pig lens. A novel NADPH:quinone oxidoreductase". J. Biol. Chem. 267 (1): 96–102. doi:10.1016/S0021-9258(18)48464-5. PMID 1370456.