NAP1L1

Nucleosome assembly protein 1-like 1 is a protein that in humans is encoded by the NAP1L1 gene.

NAP1L1
Identifiers
Aliases	NAP1L1, NAP1, NAP1L, NRP, nucleosome assembly protein 1 like 1
External IDs	OMIM: 164060; MGI: 1855693; HomoloGene: 129218; GeneCards: NAP1L1; OMA:NAP1L1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q21.2 Start 76,036,585 bp End 76,084,735 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ganglionic eminence ventricular zone secondary oocyte ovary lower lobe of lung left ovary right lung right ovary monocyte n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component melanosome membrane nucleus cytoplasm Biological process DNA replication nucleosome assembly positive regulation of cell population proliferation nervous system development positive regulation of neurogenesis positive regulation of neural precursor cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4673 53605 Ensembl ENSG00000187109 n/a UniProt P55209 P28656 RefSeq (mRNA) NM_001307924 NM_004537 NM_139207 NM_001330231 NM_001330232 NM_001146707 NM_015781 NM_001358932 RefSeq (protein) NP_001294853 NP_001317160 NP_001317161 NP_004528 NP_631946 NP_056596 NP_001345861 Location (UCSC) Chr 12: 76.04 – 76.08 Mb n/a PubMed search
Wikidata
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This gene encodes a member of the nucleosome assembly protein (NAP) family. This protein participates in DNA replication and may play a role in modulating chromatin formation and contribute to the regulation of cell proliferation. Alternative splicing of this gene results in several transcript variants; however, not all have been fully described.

Further reading

• Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
• Asahara H, Tartare-Deckert S, Nakagawa T, et al. (2002). "Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro". Mol. Cell. Biol. 22 (9): 2974–83. doi:10.1128/MCB.22.9.2974-2983.2002. PMC 133748. PMID 11940655.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Rehtanz M, Schmidt HM, Warthorst U, Steger G (2004). "Direct interaction between nucleosome assembly protein 1 and the papillomavirus E2 proteins involved in activation of transcription". Mol. Cell. Biol. 24 (5): 2153–68. doi:10.1128/MCB.24.5.2153-2168.2004. PMC 350572. PMID 14966293.
• Kho Y, Kim SC, Jiang C, et al. (2004). "A tagging-via-substrate technology for detection and proteomics of farnesylated proteins". Proc. Natl. Acad. Sci. U.S.A. 101 (34): 12479–84. Bibcode:2004PNAS..10112479K. doi:10.1073/pnas.0403413101. PMC 515085. PMID 15308774.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Okuwaki M, Kato K, Shimahara H, et al. (2005). "Assembly and disassembly of nucleosome core particles containing histone variants by human nucleosome assembly protein I." Mol. Cell. Biol. 25 (23): 10639–51. doi:10.1128/MCB.25.23.10639-10651.2005. PMC 1291234. PMID 16287874.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Eckey M, Hong W, Papaioannou M, Baniahmad A (2007). "The nucleosome assembly activity of NAP1 is enhanced by Alien". Mol. Cell. Biol. 27 (10): 3557–68. doi:10.1128/MCB.01106-06. PMC 1899999. PMID 17339334.