NCR2

NCR2
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1HKF
Identifiers
Aliases	NCR2, CD336, LY95, NK-p44, NKP44, dJ149M18.1, natural cytotoxicity triggering receptor 2
External IDs	OMIM: 604531; HomoloGene: 130365; GeneCards: NCR2; OMA:NCR2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	41,350,889 bp
RNA expression pattern
	Top expressed in
	testicle; ; tibialis anterior muscle; ; mucosa of ileum; ; deltoid muscle; ; tendon of biceps brachii; ; secondary oocyte; ; amniotic fluid; ; lateral nuclear group of thalamus; ; cardia; ; synovial joint;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transmembrane signaling receptor activity; protein binding; signaling receptor activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; cell surface;
Biological process	cellular defense response; innate immune response; signal transduction; regulation of immune response; regulation of innate immune response;
	Sources:Amigo / QuickGO
Orthologs
	9436
	n/a
	ENSG00000096264
	n/a
	O95944
	n/a
	NM_004828; NM_001199509; NM_001199510
	n/a
	NP_001186438; NP_001186439; NP_004819
	n/a
	Wikidata
View/Edit Human

Natural cytotoxicity triggering receptor 2 is a protein that in humans is encoded by the NCR2 gene.^[3]^[4] NCR2 has also been designated as CD336 (cluster of differentiation 336), NKp44, NKP44; NK-p44, LY95, and dJ149M18.1.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000096264 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cantoni C, Bottino C, Vitale M, Pessino A, Augugliaro R, Malaspina A, Parolini S, Moretta L, Moretta A, Biassoni R (Jun 1999). "NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily". J Exp Med. 189 (5): 787–96. doi:10.1084/jem.189.5.787. PMC 2192947. PMID 10049942.
^ "Entrez Gene: NCR2 natural cytotoxicity triggering receptor 2".
^ "NCR2 natural cytotoxicity triggering receptor 2 [Homo sapiens (human)] - Gene - NCBI".

Hershkovitz O, Jivov S, Bloushtain N, et al. (2007). "Characterization of the recognition of tumor cells by the natural cytotoxicity receptor, NKp44". Biochemistry. 46 (25): 7426–36. doi:10.1021/bi7000455. PMID 17536787.
Forte P, Lilienfeld BG, Baumann BC, Seebach JD (2005). "Human NK cytotoxicity against porcine cells is triggered by NKp44 and NKG2D". J. Immunol. 175 (8): 5463–70. doi:10.4049/jimmunol.175.8.5463. PMID 16210654.
Fuchs A, Cella M, Kondo T, Colonna M (2005). "Paradoxic inhibition of human natural interferon-producing cells by the activating receptor NKp44". Blood. 106 (6): 2076–82. doi:10.1182/blood-2004-12-4802. PMID 15941912.
Poggi A, Massaro AM, Negrini S, et al. (2005). "Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors". J. Immunol. 174 (5): 2653–60. doi:10.4049/jimmunol.174.5.2653. PMID 15728472.
Nowbakht P, Ionescu MC, Rohner A, et al. (2005). "Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias". Blood. 105 (9): 3615–22. doi:10.1182/blood-2004-07-2585. PMID 15657183.
Campbell KS, Yusa S, Kikuchi-Maki A, Catina TL (2004). "NKp44 triggers NK cell activation through DAP12 association that is not influenced by a putative cytoplasmic inhibitory sequence". J. Immunol. 172 (2): 899–906. doi:10.4049/jimmunol.172.2.899. PMID 14707061.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Cantoni C, Ponassi M, Biassoni R, et al. (2004). "The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity". Structure. 11 (6): 725–34. doi:10.1016/S0969-2126(03)00095-9. PMID 12791260.
Augugliaro R, Parolini S, Castriconi R, et al. (2003). "Selective cross-talk among natural cytotoxicity receptors in human natural killer cells". Eur. J. Immunol. 33 (5): 1235–41. doi:10.1002/eji.200323896. PMID 12731048. S2CID 10724743.
Allcock RJ, Barrow AD, Forbes S, et al. (2003). "The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44". Eur. J. Immunol. 33 (2): 567–77. doi:10.1002/immu.200310033. PMID 12645956. S2CID 27147251.
Cantoni C, Ponassi M, Biassoni R, et al. (2003). "Crystallization and preliminary crystallographic characterization of the extracellular Ig-like domain of human natural killer cell activating receptor NKp44". Acta Crystallogr. D. 58 (Pt 10 Pt 2): 1843–5. doi:10.1107/S0907444902012325. PMID 12351833.

External links

NCR2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
PDBe-KB provides an overview of all the structure information available in the PDB for Human Natural cytotoxicity triggering receptor 2 (NCR2)

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000096264 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10049942-3] Cantoni C, Bottino C, Vitale M, Pessino A, Augugliaro R, Malaspina A, Parolini S, Moretta L, Moretta A, Biassoni R (Jun 1999). "NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily". J Exp Med. 189 (5): 787–96. doi:10.1084/jem.189.5.787. PMC 2192947. PMID 10049942.

[entrez-4] "Entrez Gene: NCR2 natural cytotoxicity triggering receptor 2".

[5] "NCR2 natural cytotoxicity triggering receptor 2 [Homo sapiens (human)] - Gene - NCBI".

[3]

[4]

[5]

[1]

[2]

NCR2

References

Further reading

External links