NECAB3

N-terminal EF-hand calcium-binding protein 3 is a protein that in humans is encoded by the NECAB3 gene.

NECAB3
Identifiers
Aliases	NECAB3, APBA2BP, EFCBP3, NIP1, STIP3, SYTIP2, XB51, dJ63M2.4, dJ63M2.5, N-terminal EF-hand calcium binding protein 3
External IDs	OMIM: 612478; MGI: 1861721; HomoloGene: 10992; GeneCards: NECAB3; OMA:NECAB3 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) Band 20q11.22 Start 33,657,087 bp End 33,674,463 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 H1 Start 154,386,319 bp End 154,400,810 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex left adrenal cortex left ovary right ovary muscle of thigh apex of heart gastric mucosa gastrocnemius muscle body of stomach right lobe of thyroid gland Top expressed in habenula superior frontal gyrus primary visual cortex spermatid dentate gyrus of hippocampal formation granule cell lumbar spinal ganglion embryo prefrontal cortex anterior horn of spinal cord cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding protein binding metal ion binding Cellular component nucleus cytoplasm endoplasmic reticulum membrane endoplasmic reticulum Golgi cis cisterna Golgi apparatus Biological process protein secretion protein metabolic process regulation of amyloid precursor protein biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 63941 56846 Ensembl ENSG00000125967 ENSMUSG00000027489 UniProt Q96P71 Q9D6J4 RefSeq (mRNA) NM_031231 NM_031232 NM_021546 NM_001379147 NM_001379148 NM_001379149 RefSeq (protein) NP_112508 NP_112509 NP_067521 NP_001366076 NP_001366077 NP_001366078 Location (UCSC) Chr 20: 33.66 – 33.67 Mb Chr 2: 154.39 – 154.4 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene interacts with the amino-terminal domain of the amyloid beta A4 precursor protein-binding family A member 2 (APBA2), inhibits the association of APBA2 with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by APBA2. This protein, together with APBA2, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. This gene consists of at least 13 exons and its alternative splicing generates at least 2 transcript variants.

See also

• N-terminal
• EF-hand

External links

• Human NECAB3 genome location and NECAB3 gene details page in the UCSC Genome Browser.

Further reading

• Büssow K, Cahill D, Nietfeld W, et al. (1998). "A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library". Nucleic Acids Res. 26 (21): 5007–8. doi:10.1093/nar/26.21.5007. PMC 147919. PMID 9776767.
• Sugita S, Südhof TC (2000). "Specificity of Ca2+-dependent protein interactions mediated by the C2A domains of synaptotagmins". Biochemistry. 39 (11): 2940–9. doi:10.1021/bi9920984. PMID 10715114.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
• Sugita S, Ho A, Südhof TC (2002). "NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern". Neuroscience. 112 (1): 51–63. doi:10.1016/S0306-4522(02)00063-5. PMID 12044471. S2CID 18740496.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sumioka A, Imoto S, Martins RN, et al. (2003). "XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms". Biochem. J. 374 (Pt 1): 261–8. doi:10.1042/BJ20030489. PMC 1223589. PMID 12780348.
• Yoo JC, Chang JR, Kim SH, et al. (2004). "NIP1/XB51/NECAB3 is a potential substrate of Nek2, suggesting specific roles of Nek2 in Golgi". Exp. Cell Res. 292 (2): 393–402. doi:10.1016/j.yexcr.2003.09.025. PMID 14697346.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.