Neural precursor cell expressed, developmentally down-regulated 1, also known as Nedd1, is a human gene[5] and encodes the protein NEDD1.

NEDD1
Identifiers
AliasesNEDD1, GCP-WD, TUBGCP7, neural precursor cell expressed, developmentally down-regulated 1, NEDD1 gamma-tubulin ring complex targeting factor
External IDsOMIM: 600372; MGI: 97293; HomoloGene: 7439; GeneCards: NEDD1; OMA:NEDD1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001135175
NM_001135176
NM_001135177
NM_152905

NM_008682

RefSeq (protein)

NP_001128647
NP_001128648
NP_001128649
NP_690869

NP_032708

Location (UCSC)Chr 12: 96.91 – 96.95 MbChr 10: 92.52 – 92.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

NEDD1 is localized in the centrosome and it plays a role in mitosis through its interaction with γ-tubulin. WD40 repeats are located in the amino-terminal of the protein and are responsible for NEDD1 localization in the centrosome, and the carboxy-terminal amino acids are needed for interactions with γ-tubulin. Depletion of NEDD1 causes impaired centrosome and chromatin microtubules assembly that results in the failure of microtubule nucleation and prevents proper spindle formation.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000139350Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019988Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: NEDD1 neural precursor cell expressed, developmentally down-regulated 1".

Further reading

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