NFKBIB

NF-kappa-B inhibitor beta is a protein that in humans is encoded by the NFKBIB gene.

NFKBIB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1K3Z, 1OY3
Identifiers
Aliases	NFKBIB, IKBB, TRIP9, NFKB inhibitor beta
External IDs	OMIM: 604495; MGI: 104752; HomoloGene: 37631; GeneCards: NFKBIB; OMA:NFKBIB - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.2 Start 38,899,700 bp End 38,908,893 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 B1 Start 28,457,676 bp End 28,466,937 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis granulocyte gastrocnemius muscle C1 segment mucosa of transverse colon blood substantia nigra right lobe of liver putamen Top expressed in seminiferous tubule muscle of thigh granulocyte right kidney embryo embryo lip yolk sac ankle secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity transcription coactivator activity protein binding Cellular component cytoplasm nucleus cytosol Biological process transcription, DNA-templated cellular response to lipopolysaccharide signal transduction positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4793 18036 Ensembl ENSG00000104825 ENSG00000282905 ENSMUSG00000030595 UniProt Q15653 Q60778 RefSeq (mRNA) NM_001001716 NM_001243116 NM_002503 NM_001369699 NM_001369700 NM_010908 NM_001306222 RefSeq (protein) NP_001230045 NP_002494 NP_001356628 NP_001356629 NP_001293151 NP_035038 Location (UCSC) Chr 19: 38.9 – 38.91 Mb Chr 7: 28.46 – 28.47 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]

Interactions

NFKBIB has been shown to interact with:

• IKK2,
• RELA, and
• Retinoid X receptor alpha.

Further reading

• Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol. Endocrinol. 9 (2): 243–54. doi:10.1210/mend.9.2.7776974. PMID 7776974.
• Harhaj E, Blaney J, Millhouse S, Sun SC (1996). "Differential effects of I kappa B molecules on Tat-mediated transactivation of HIV-1 LTR". Virology. 216 (1): 284–7. doi:10.1006/viro.1996.0062. PMID 8615004.
• DiDonato J, Mercurio F, Rosette C, Wu-Li J, Suyang H, Ghosh S, Karin M (1996). "Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation". Mol. Cell. Biol. 16 (4): 1295–304. doi:10.1128/mcb.16.4.1295. PMC 231113. PMID 8657102.
• Beauparlant P, Kwon H, Clarke M, Lin R, Sonenberg N, Wainberg M, Hiscott J (1996). "Transdominant mutants of I kappa B alpha block Tat-tumor necrosis factor synergistic activation of human immunodeficiency virus type 1 gene expression and virus multiplication". J. Virol. 70 (9): 5777–85. doi:10.1128/JVI.70.9.5777-5785.1996. PMC 190591. PMID 8709193.
• Suyang H, Phillips R, Douglas I, Ghosh S (1996). "Role of unphosphorylated, newly synthesized I kappa B beta in persistent activation of NF-kappa B". Mol. Cell. Biol. 16 (10): 5444–9. doi:10.1128/mcb.16.10.5444. PMC 231544. PMID 8816457.
• Whiteside ST, Epinat JC, Rice NR, Israël A (1997). "I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity". EMBO J. 16 (6): 1413–26. doi:10.1093/emboj/16.6.1413. PMC 1169738. PMID 9135156.
• DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M (1997). "A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB". Nature. 388 (6642): 548–54. Bibcode:1997Natur.388..548D. doi:10.1038/41493. PMID 9252186. S2CID 4354442.
• McKinsey TA, Chu ZL, Ballard DW (1997). "Phosphorylation of the PEST domain of IkappaBbeta regulates the function of NF-kappaB/IkappaBbeta complexes". J. Biol. Chem. 272 (36): 22377–80. doi:10.1074/jbc.272.36.22377. PMID 9278383.
• Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV (1997). "IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK". Science. 278 (5339): 866–9. Bibcode:1997Sci...278..866W. doi:10.1126/science.278.5339.866. PMID 9346485.
• Na SY, Kim HJ, Lee SK, Choi HS, Na DS, Lee MO, Chung M, Moore DD, Lee JW (1998). "IkappaBbeta interacts with the retinoid X receptor and inhibits retinoid-dependent transactivation in lipopolysaccharide-treated cells". J. Biol. Chem. 273 (6): 3212–5. doi:10.1074/jbc.273.6.3212. PMID 9452433.
• Lee FS, Peters RT, Dang LC, Maniatis T (1998). "MEKK1 activates both IκB kinase α and IκB kinase β". Proc. Natl. Acad. Sci. U.S.A. 95 (16): 9319–24. Bibcode:1998PNAS...95.9319L. doi:10.1073/pnas.95.16.9319. PMC 21336. PMID 9689078.
• Zandi E, Chen Y, Karin M (1998). "Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate". Science. 281 (5381): 1360–3. doi:10.1126/science.281.5381.1360. PMID 9721103.
• Blázquez MV, Macho A, Ortiz C, Lucena C, López-Cabrera M, Sánchez-Madrid F, Muñoz E (1999). "Extracellular HIV type 1 Tat protein induces CD69 expression through NF-kappaB activation: possible correlation with cell surface Tat-binding proteins". AIDS Res. Hum. Retroviruses. 15 (13): 1209–18. doi:10.1089/088922299310304. PMID 10480634.
• Wu C, Ghosh S (1999). "beta-TrCP mediates the signal-induced ubiquitination of IkappaBbeta". J. Biol. Chem. 274 (42): 29591–4. doi:10.1074/jbc.274.42.29591. PMID 10514424.
• Kumar A, Dhawan S, Mukhopadhyay A, Aggarwal BB (2000). "Human immunodeficiency virus-1-tat induces matrix metalloproteinase-9 in monocytes through protein tyrosine phosphatase-mediated activation of nuclear transcription factor NF-kappaB". FEBS Lett. 462 (1–2): 140–4. doi:10.1016/S0014-5793(99)01487-8. PMID 10580107. S2CID 86721940.
• Fenwick C, Na SY, Voll RE, Zhong H, Im SY, Lee JW, Ghosh S (2000). "A subclass of Ras proteins that regulate the degradation of IkappaB". Science. 287 (5454): 869–73. Bibcode:2000Sci...287..869F. doi:10.1126/science.287.5454.869. PMID 10657303.
• Manna SK, Aggarwal BB (2000). "Differential requirement for p56lck in HIV-tat versus TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal kinase, and apoptosis". J. Immunol. 164 (10): 5156–66. doi:10.4049/jimmunol.164.10.5156. PMID 10799874.
• Li X, Josef J, Marasco WA (2001). "Hiv-1 Tat can substantially enhance the capacity of NIK to induce IkappaB degradation". Biochem. Biophys. Res. Commun. 286 (3): 587–94. doi:10.1006/bbrc.2001.5442. PMID 11511100.
• Page M, Tuckerman EM, Li TC, Laird SM (2002). "Expression of nuclear factor kappa B components in human endometrium". J. Reprod. Immunol. 54 (1–2): 1–13. doi:10.1016/S0165-0378(01)00122-X. PMID 11839392.