NFKBIL1

NF-kappa-B inhibitor-like protein 1 is a protein that in humans is encoded by the NFKBIL1 gene.

NFKBIL1
Identifiers
Aliases	NFKBIL1, IKBL, LST1, NFKBIL, NFKB inhibitor like 1
External IDs	OMIM: 601022; MGI: 1340031; HomoloGene: 3671; GeneCards: NFKBIL1; OMA:NFKBIL1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.33 Start 31,546,870 bp End 31,558,829 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 B1|17 18.6 cM Start 35,439,151 bp End 35,454,768 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle body of pancreas body of stomach fundus apex of heart left ovary gastric mucosa right ovary muscle layer of sigmoid colon gastrocnemius muscle Top expressed in granulocyte muscle of thigh internal carotid artery spermatid external carotid artery ventricular zone seminiferous tubule fossa spermatocyte epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytosol nucleus Biological process cytoplasmic sequestering of transcription factor negative regulation of tumor necrosis factor production negative regulation of toll-like receptor signaling pathway I-kappaB kinase/NF-kappaB signaling negative regulation of NF-kappaB transcription factor activity cellular response to lipopolysaccharide negative regulation of lipopolysaccharide-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4795 18038 Ensembl ENSG00000206440 ENSG00000234530 ENSG00000236346 ENSG00000235125 ENSG00000236196 ENSG00000204498 ENSG00000227565 ENSMUSG00000042419 UniProt Q9UBC1 O88995 RefSeq (mRNA) NM_005007 NM_001144961 NM_001144962 NM_001144963 NM_010909 NM_001364909 RefSeq (protein) NP_001138433 NP_001138434 NP_001138435 NP_004998 NP_035039 NP_001351838 Location (UCSC) Chr 6: 31.55 – 31.56 Mb Chr 17: 35.44 – 35.45 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a divergent member of the I-kappa-B family of proteins. Its function is unclear. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6.

Further reading

• Iris FJ, Bougueleret L, Prieur S, Caterina D, Primas G, Perrot V, Jurka J, Rodriguez-Tome P, Claverie JM, Dausset J (Feb 1993). "Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment". Nature Genetics. 3 (2): 137–45. doi:10.1038/ng0293-137. PMID 8499947. S2CID 33041319.
• Shiina T, Tamiya G, Oka A, Yamagata T, Yamagata N, Kikkawa E, Goto K, Mizuki N, Watanabe K, Fukuzumi Y, Taguchi S, Sugawara C, Ono A, Chen L, Yamazaki M, Tashiro H, Ando A, Ikemura T, Kimura M, Inoko H (Feb 1998). "Nucleotide sequencing analysis of the 146-kilobase segment around the IkBL and MICA genes at the centromeric end of the HLA class I region". Genomics. 47 (3): 372–82. doi:10.1006/geno.1997.5114. PMID 9480751.
• Neville MJ, Campbell RD (Apr 1999). "A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC". Journal of Immunology. 162 (8): 4745–54. doi:10.4049/jimmunol.162.8.4745. PMID 10202016.
• Allcock RJ, Christiansen FT, Price P (Jul 1999). "The central MHC gene IKBL carries a structural polymorphism that is associated with HLA-A3,B7,DR15". Immunogenetics. 49 (7–8): 660–5. doi:10.1007/s002510050662. PMID 10369924. S2CID 32440895.
• Okamoto K, Makino S, Yoshikawa Y, Takaki A, Nagatsuka Y, Ota M, Tamiya G, Kimura A, Bahram S, Inoko H (Feb 2003). "Identification of I kappa BL as the second major histocompatibility complex-linked susceptibility locus for rheumatoid arthritis". American Journal of Human Genetics. 72 (2): 303–12. doi:10.1086/346067. PMC 379224. PMID 12509789.
• Lin CH, Cho CL, Tsai WC, Ou TT, Wu CC, Yen JH, Liu HW (Jun 2006). "Inhibitors of kB-like gene polymorphisms in rheumatoid arthritis". Immunology Letters. 105 (2): 193–7. doi:10.1016/j.imlet.2006.03.003. PMID 16644022.
• Glas J, Török HP, Tonenchi L, Müller-Myhsok B, Mussack T, Wetzke M, Klein W, Epplen JT, Griga T, Schiemann U, Lohse P, Seiderer J, Schnitzler F, Brand S, Ochsenkühn T, Folwaczny M, Folwaczny C (Jul 2006). "Role of the NFKB1 -94ins/delATTG promoter polymorphism in IBD and potential interactions with polymorphisms in the CARD15/NOD2, IKBL, and IL-1RN genes". Inflammatory Bowel Diseases. 12 (7): 606–11. doi:10.1097/01.ibd.0000225346.23765.6b. PMID 16804398. S2CID 25535173.
• Koch W, Hoppmann P, Michou E, Jung V, Pfeufer A, Mueller JC, Gieger C, Wichmann HE, Meitinger T, Schömig A, Kastrati A (Aug 2007). "Association of variants in the BAT1-NFKBIL1-LTA genomic region with protection against myocardial infarction in Europeans". Human Molecular Genetics. 16 (15): 1821–7. doi:10.1093/hmg/ddm130. PMID 17517687.
• Ramasawmy R, Faé KC, Cunha-Neto E, Borba SC, Ianni B, Mady C, Goldberg AC, Kalil J (Jan 2008). "Variants in the promoter region of IKBL/NFKBIL1 gene may mark susceptibility to the development of chronic Chagas' cardiomyopathy among Trypanosoma cruzi-infected individuals". Molecular Immunology. 45 (1): 283–8. doi:10.1016/j.molimm.2007.04.015. PMID 17544510.
• Kariz S, Milutinović A, Bregar D, Terzić I, Terzić R, Lovrecić L, Herova M, Hruskovicova H, Peterlin B, Petrovic D, Zorc-Pleskovic R (Jun 2007). "The interleukin-1 receptor antagonist gene and the inhibitor of kappa B-like protein gene polymorphisms are not associated with myocardial infarction in Slovene population with type 2 diabetes". Collegium Antropologicum. 31 (2): 503–7. PMID 17847930.