NK3 homeobox 3, also known as NKX3-3, zax, bagpipe homeobox or zampogna is a paralogous gene of NKX3-2. It is named after the italian instrument called zampogna.[1] NKX3-3 is not present in the human genome.[2]

Function

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NKX3-3 is a homeodomain transcription factor. It plays a role in the development of the larval skeleton of anuran tadpoles. A knockdown of this NKX3-2 related homeobox gene in Xenopus laevis causes fatal head deformation, disappearing of jaw cartilages and shifted muscular insertions.[3]

References

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  1. ^ Newman CS, Krieg PA (February 1999). "The Xenopus bagpipe-related homeobox gene zampogna is expressed in the pharyngeal endoderm and the visceral musculature of the midgut". Development Genes and Evolution. 209 (2): 132–4. doi:10.1007/s004270050236. PMID 10022957. S2CID 13512639.
  2. ^ Watanabe M (June 2017). "Conservatism and variability of gene expression profiles among homeologous transcription factors in Xenopus laevis". Developmental Biology. 426 (2): 301–24. doi:10.1016/j.ydbio.2016.09.017. PMID 27810169.
  3. ^ Lukas, Paul; Schmidt, Jennifer; Olsson, Lennart (2020). "Knockdown of zax in Xenopus laevis leads to craniofacial malformations and the absence of the intramandibular joint". Vertebrate Zoology. 70 (1): 14. doi:10.26049/VZ70-1-2020-02.

Further reading

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