NK3 homeobox 3, also known as NKX3-3, zax, bagpipe homeobox or zampogna is a paralogous gene of NKX3-2. It is named after the italian instrument called zampogna.[1] NKX3-3 is not present in the human genome.[2]
Function
editNKX3-3 is a homeodomain transcription factor. It plays a role in the development of the larval skeleton of anuran tadpoles. A knockdown of this NKX3-2 related homeobox gene in Xenopus laevis causes fatal head deformation, disappearing of jaw cartilages and shifted muscular insertions.[3]
References
edit- ^ Newman CS, Krieg PA (February 1999). "The Xenopus bagpipe-related homeobox gene zampogna is expressed in the pharyngeal endoderm and the visceral musculature of the midgut". Development Genes and Evolution. 209 (2): 132–4. doi:10.1007/s004270050236. PMID 10022957. S2CID 13512639.
- ^ Watanabe M (June 2017). "Conservatism and variability of gene expression profiles among homeologous transcription factors in Xenopus laevis". Developmental Biology. 426 (2): 301–24. doi:10.1016/j.ydbio.2016.09.017. PMID 27810169.
- ^ Lukas, Paul; Schmidt, Jennifer; Olsson, Lennart (2020). "Knockdown of zax in Xenopus laevis leads to craniofacial malformations and the absence of the intramandibular joint". Vertebrate Zoology. 70 (1): 14. doi:10.26049/VZ70-1-2020-02.
Further reading
edit- Square T, Jandzik D, Cattell M, Coe A, Doherty J, Medeiros MM (2015). "A gene expression map of the larvalXenopus laevishead reveals developmental changes underlying the evolution of new skeletal elements". Developmental Biology. 397 (2): 293–304. doi:10.1016/j.ydbio.2014.10.016. PMID 25446275.
External links
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