In molecular biology, NPPA antisense RNA 1 (non-protein coding), also known as NPPA-AS1 is a long non-coding RNA. It is an antisense transcript of the NPPA gene, which encodes the precursor of cardiodilatin-related peptide and atrial natriuretic factor. NPPA-AS1 is alternatively spliced. At least one isoform of NPPA-AS1 can regulate the expression of spliced and unspliced variants of NPPA, possibly by the formation of duplexes with NPPA mRNA.[1]
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edit- ^ Annilo T, Kepp K, Laan M (2009). "Natural antisense transcript of natriuretic peptide precursor A (NPPA): structural organization and modulation of NPPA expression". BMC Mol Biol. 10: 81. doi:10.1186/1471-2199-10-81. PMC 2731763. PMID 19671135.