NPTXR

Neuronal pentraxin receptor is a protein that in humans is encoded by the NPTXR gene.

NPTXR
Identifiers
Aliases	NPTXR, NPR, neuronal pentraxin receptor
External IDs	OMIM: 609474; MGI: 1920590; HomoloGene: 8620; GeneCards: NPTXR; OMA:NPTXR - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q13.1 Start 38,818,452 bp End 38,844,028 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15 E1|15 37.85 cM Start 79,670,552 bp End 79,688,967 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 10 frontal pole Region I of hippocampus proper right frontal lobe cingulate gyrus anterior cingulate cortex dorsolateral prefrontal cortex amygdala Brodmann area 9 orbitofrontal cortex Top expressed in piriform cortex subiculum dentate gyrus of hippocampal formation granule cell primary visual cortex anterior amygdaloid area superior frontal gyrus habenula primary motor cortex cingulate gyrus medial dorsal nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding Cellular component membrane integral component of membrane plasma membrane cytoplasmic side of plasma membrane filopodium dendrite growth cone soma glutamatergic synapse Biological process neuron projection development regulation of postsynaptic neurotransmitter receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23467 73340 Ensembl ENSG00000221890 ENSMUSG00000022421 UniProt O95502 Q99J85 RefSeq (mRNA) NM_058178 NM_014293 NM_030689 RefSeq (protein) NP_055108 n/a Location (UCSC) Chr 22: 38.82 – 38.84 Mb Chr 15: 79.67 – 79.69 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat protein pentraxin is thought to mediate neuronal uptake of synaptic material and the presynaptic snake venom toxin, taipoxin. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also be true for human and mouse, based on strong sequence conservation amongst these species.

See also

• NPTX2, Neuronal pentraxin II

Further reading

• Poulsen TT, Pedersen N, Perin MS, et al. (2006). "Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin". Lung Cancer. 50 (3): 329–37. doi:10.1016/j.lungcan.2005.06.011. PMID 16115696.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kirkpatrick LL, Matzuk MM, Dodds DC, Perin MS (2000). "Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2". J. Biol. Chem. 275 (23): 17786–92. doi:10.1074/jbc.M002254200. PMID 10748068.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
• Dodds DC, Omeis IA, Cushman SJ, et al. (1997). "Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49". J. Biol. Chem. 272 (34): 21488–94. doi:10.1074/jbc.272.34.21488. PMID 9261167.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.