NRON also known as ncRNA repressor of the nuclear factor of activated T cells is a non-coding RNA involved in repressing NFAT.[1] The function of this ncRNA was identified by a large-scale screen of 512 non-coding RNAs discovered in earlier EST sequencing projects.[2][3]
| ncRNA Repressor of NFAT (nuclear factor of activated T cells) | |
|---|---|
 Predicted secondary structure and sequence conservation of NRON | |
| Identifiers | |
| Symbol | NRON |
| Rfam | RF00636 |
| Other data | |
| RNA type | Gene |
| Domain(s) | Eukaryota |
| SO | SO:0001263 |
| PDB structures | PDBe |
Each of the RNAs that were conserved between human and mouse were knocked down using shRNAs. The resulting cell-lines were screened for changes in activity of NFAT.
References
edit- ^ Willingham AT, Orth AP, Batalov S, Peters EC, Wen BG, Aza-Blanc P, Hogenesch JB, Schultz PG (September 2005). "A strategy for probing the function of noncoding RNAs finds a repressor of NFAT". Science. 309 (5740): 1570–1573. doi:10.1126/science.1115901. PMID 16141075. S2CID 22717118.
- ^ Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, et al. (December 2002). "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs" (PDF). Nature. 420 (6915): 563–573. doi:10.1038/nature01266. PMID 12466851.
- ^ Numata K, Kanai A, Saito R, Kondo S, Adachi J, Wilming LG, Hume DA, Hayashizaki Y, Tomita M (June 2003). "Identification of putative noncoding RNAs among the RIKEN mouse full-length cDNA collection". Genome Research. 13 (6B): 1301–1306. doi:10.1101/gr.1011603. PMC 403720. PMID 12819127.
External links
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