NTN5

NTN5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4URT
Identifiers
Aliases	NTN5, netrin 5
External IDs	MGI: 2685330; HomoloGene: 17106; GeneCards: NTN5; OMA:NTN5 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	48,673,081 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,343,980 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; pituitary gland; ; anterior pituitary; ; left ovary; ; right ovary; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; left uterine tube; ; granulocyte; ; canal of the cervix;
	Top expressed in
	gastrula; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; seminiferous tubule; ; superior frontal gyrus; ; cervix; ; embryo; ; hippocampus proper; ; stria vascularis; ; nerve;
	More reference expression data
	n/a
Orthologs
	126147
	243967
	ENSG00000142233
	ENSMUSG00000070564
	Q8WTR8
	Q3UQ22
	NM_145807
	NM_001033356; NM_001289692; NM_001289693; NM_001358870
	NP_665806
	NP_001028528; NP_001276621; NP_001276622; NP_001345799
	Wikidata
View/Edit Human	View/Edit Mouse

Netrin-5 (NTN5), also known as netrin-1-like protein, is a protein that in humans is encoded by the NTN5 gene.^[5] Netrin-5 is included in the family of secreted laminin-related proteins.

Function

Netrin-5 functions are not fully clarified. However, it is believed to:

Plays an important role in neurogenesis by controlling the development of dendrites and acting as a guide for axons.^[6]^[7]
Regulates cell migration in the brain during embryonic development.^[8]
Prevents motor neuron cell body migration out of the neural tube.^[8]

Clinical significance

A recent genome-wide association study (GWAS) has found that genetic variations in HAVCR2 are associated with late-onset sporadic Alzheimer’s disease (LOAD). However, it's unknown how netrin-5 mutation contributes to disease.^[9]

Considering the role of NTN5 in cell migration, it is very possible that netrin-5 has an important role in human carcinogenesis, although currently no tumor type with NTN5 alterations has been identified.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000142233 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000070564 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "NTN5 netrin 5 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2021-12-11.
^ Yamagishi S, Yamada K, Sawada M, Nakano S, Mori N, Sawamoto K, et al. (2015). "Netrin-5 is highly expressed in neurogenic regions of the adult brain". Frontiers in Cellular Neuroscience. 9: 146. doi:10.3389/fncel.2015.00146. PMC 4403520. PMID 25941474.
^ Ikegaya S, Iga Y, Mikawa S, Zhou L, Abe M, Sakimura K, et al. (2020). "Decreased Proliferation in the Neurogenic Niche, Disorganized Neuroblast Migration, and Increased Oligodendrogenesis in Adult Netrin-5-Deficient Mice". Frontiers in Neuroscience. 14: 570974. doi:10.3389/fnins.2020.570974. PMC 7726356. PMID 33324143.
^ ^a ^b Gaudet P, Livstone MS, Lewis SE, Thomas PD (September 2011). "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium". Briefings in Bioinformatics. 12 (5): 449–462. doi:10.1093/bib/bbr042. PMC 3178059. PMID 21873635.
^ Wightman DP, Jansen IE, Savage JE, Shadrin AA, Bahrami S, Holland D, et al. (September 2021). "A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease". Nature Genetics. 53 (9): 1276–1282. doi:10.1038/s41588-021-00921-z. hdl:1871.1/61f01aa9-6dc7-4213-be2a-d3fe622db488. PMC 10243600. PMID 34493870. S2CID 237442349.
^ Bruikman CS, Zhang H, Kemper AM, van Gils JM (2019-02-24). "Netrin Family: Role for Protein Isoforms in Cancer". Journal of Nucleic Acids. 2019: 3947123. doi:10.1155/2019/3947123. PMC 6408995. PMID 30923634.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000142233 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000070564 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "NTN5 netrin 5 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2021-12-11.

[6] Yamagishi S, Yamada K, Sawada M, Nakano S, Mori N, Sawamoto K, et al. (2015). "Netrin-5 is highly expressed in neurogenic regions of the adult brain". Frontiers in Cellular Neuroscience. 9: 146. doi:10.3389/fncel.2015.00146. PMC 4403520. PMID 25941474.

[7] Ikegaya S, Iga Y, Mikawa S, Zhou L, Abe M, Sakimura K, et al. (2020). "Decreased Proliferation in the Neurogenic Niche, Disorganized Neuroblast Migration, and Increased Oligodendrogenesis in Adult Netrin-5-Deficient Mice". Frontiers in Neuroscience. 14: 570974. doi:10.3389/fnins.2020.570974. PMC 7726356. PMID 33324143.

[:0-8] Gaudet P, Livstone MS, Lewis SE, Thomas PD (September 2011). "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium". Briefings in Bioinformatics. 12 (5): 449–462. doi:10.1093/bib/bbr042. PMC 3178059. PMID 21873635.

[9] Wightman DP, Jansen IE, Savage JE, Shadrin AA, Bahrami S, Holland D, et al. (September 2021). "A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease". Nature Genetics. 53 (9): 1276–1282. doi:10.1038/s41588-021-00921-z. hdl:1871.1/61f01aa9-6dc7-4213-be2a-d3fe622db488. PMC 10243600. PMID 34493870. S2CID 237442349.

[10] Bruikman CS, Zhang H, Kemper AM, van Gils JM (2019-02-24). "Netrin Family: Role for Protein Isoforms in Cancer". Journal of Nucleic Acids. 2019: 3947123. doi:10.1155/2019/3947123. PMC 6408995. PMID 30923634.

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