NUDT5

ADP-sugar pyrophosphatase is an enzyme that in humans is encoded by the NUDT5 gene.

NUDT5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DSB, 2DSC, 2DSD, 3AC9, 3ACA, 3BM4, 3L85
Identifiers
Aliases	NUDT5, YSA1, YSA1H, YSAH1, hYSAH1, nudix hydrolase 5, hNUDT5
External IDs	OMIM: 609230; MGI: 1858232; HomoloGene: 5388; GeneCards: NUDT5; OMA:NUDT5 - orthologs
EC number	3.6.1.58
Gene location (Human) Chr. Chromosome 10 (human) Band 10p14 Start 12,165,330 bp End 12,196,144 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 A1 Start 5,845,019 bp End 5,871,895 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad right lobe of liver ganglionic eminence rectum stromal cell of endometrium gingival epithelium islet of Langerhans mucosa of ileum ventricular zone anterior pituitary Top expressed in otic placode gastrula embryo epiblast embryo primary oocyte primitive streak abdominal wall medullary collecting duct ventricular zone More reference expression data BioGPS n/a
Gene ontology Molecular function m7G(5')pppN diphosphatase activity hydrolase activity magnesium ion binding metal ion binding nucleoside-diphosphatase activity RNA binding ADP-sugar diphosphatase activity snoRNA binding 8-oxo-dGDP phosphatase activity protein binding transferase activity ADP-ribose diphosphatase activity protein homodimerization activity nucleotidyltransferase activity Cellular component cytosol extracellular exosome intracellular anatomical structure nucleus Biological process nucleobase-containing small molecule catabolic process ribonucleoside diphosphate catabolic process nucleobase-containing compound metabolic process nucleotide metabolic process D-ribose catabolic process chromatin remodeling ATP generation from poly-ADP-D-ribose nucleoside phosphate metabolic process ribose phosphate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11164 53893 Ensembl ENSG00000165609 ENSMUSG00000025817 UniProt Q9UKK9 Q9JKX6 RefSeq (mRNA) NM_014142 NM_001321647 NM_001321648 NM_016918 RefSeq (protein) NP_001308576 NP_001308577 NP_054861 NP_058614 Location (UCSC) Chr 10: 12.17 – 12.2 Mb Chr 2: 5.85 – 5.87 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Nudix hydrolases, such as NUDT5, eliminate toxic nucleotide derivatives from the cell and regulate the levels of important signaling nucleotides and their metabolites (McLennan, 1999).[supplied by OMIM]

Further reading

• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ishibashi T, Hayakawa H, Sekiguchi M (2004). "A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides". EMBO Rep. 4 (5): 479–83. doi:10.1038/sj.embor.embor838. PMC 1319193. PMID 12717453.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Yang H, Slupska MM, Wei YF, et al. (2000). "Cloning and characterization of a new member of the Nudix hydrolases from human and mouse". J. Biol. Chem. 275 (12): 8844–53. doi:10.1074/jbc.275.12.8844. PMID 10722730.
• Gasmi L, Cartwright JL, McLennan AG (2000). "Cloning, expression and characterization of YSA1H, a human adenosine 5'-diphosphosugar pyrophosphatase possessing a MutT motif". Biochem. J. 344 Pt 2 (Pt 2): 331–7. doi:10.1042/0264-6021:3440331. PMC 1220648. PMID 10567213.